Review of PP2A Tumor Biology and Antitumor Effects of PP2A Inhibitor LB100 in the Nervous System
Protein phosphatase 2A (PP2A) is a ubiquitous serine/threonine phosphatase implicated in a wide variety of regulatory cellular functions. PP2A is abundant in the mammalian nervous system, and dysregulation of its cellular functions is associated with myriad neurodegenerative disorders. Additionally,...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/12/3087 |
| _version_ | 1797529447671267328 |
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| author | Jean-Paul Bryant Adam Levy John Heiss Yeshavanth Kumar Banasavadi-Siddegowda |
| author_facet | Jean-Paul Bryant Adam Levy John Heiss Yeshavanth Kumar Banasavadi-Siddegowda |
| author_sort | Jean-Paul Bryant |
| collection | DOAJ |
| description | Protein phosphatase 2A (PP2A) is a ubiquitous serine/threonine phosphatase implicated in a wide variety of regulatory cellular functions. PP2A is abundant in the mammalian nervous system, and dysregulation of its cellular functions is associated with myriad neurodegenerative disorders. Additionally, PP2A has oncologic implications, recently garnering attention and emerging as a therapeutic target because of the antitumor effects of a potent PP2A inhibitor, LB100. LB100 abrogation of PP2A is believed to exert its inhibitory effects on tumor progression through cellular chemo- and radiosensitization to adjuvant agents. An updated and unifying review of PP2A biology and inhibition with LB100 as a therapeutic strategy for targeting cancers of the nervous system is needed, as other reviews have mainly covered broader applications of LB100. In this review, we discuss the role of PP2A in normal cells and tumor cells of the nervous system. Furthermore, we summarize current evidence regarding the therapeutic potential of LB100 for treating solid tumors of the nervous system. |
| first_indexed | 2024-03-10T10:14:00Z |
| format | Article |
| id | doaj.art-c2520336cdb145398125922857bf51cf |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T10:14:00Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-c2520336cdb145398125922857bf51cf2023-11-22T01:00:44ZengMDPI AGCancers2072-66942021-06-011312308710.3390/cancers13123087Review of PP2A Tumor Biology and Antitumor Effects of PP2A Inhibitor LB100 in the Nervous SystemJean-Paul Bryant0Adam Levy1John Heiss2Yeshavanth Kumar Banasavadi-Siddegowda3Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USAMiller School of Medicine, University of Miami, Miami, FL 33136, USASurgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USASurgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USAProtein phosphatase 2A (PP2A) is a ubiquitous serine/threonine phosphatase implicated in a wide variety of regulatory cellular functions. PP2A is abundant in the mammalian nervous system, and dysregulation of its cellular functions is associated with myriad neurodegenerative disorders. Additionally, PP2A has oncologic implications, recently garnering attention and emerging as a therapeutic target because of the antitumor effects of a potent PP2A inhibitor, LB100. LB100 abrogation of PP2A is believed to exert its inhibitory effects on tumor progression through cellular chemo- and radiosensitization to adjuvant agents. An updated and unifying review of PP2A biology and inhibition with LB100 as a therapeutic strategy for targeting cancers of the nervous system is needed, as other reviews have mainly covered broader applications of LB100. In this review, we discuss the role of PP2A in normal cells and tumor cells of the nervous system. Furthermore, we summarize current evidence regarding the therapeutic potential of LB100 for treating solid tumors of the nervous system.https://www.mdpi.com/2072-6694/13/12/3087PP2ALB100nervous systemtumor biologybrain tumorpreclinical |
| spellingShingle | Jean-Paul Bryant Adam Levy John Heiss Yeshavanth Kumar Banasavadi-Siddegowda Review of PP2A Tumor Biology and Antitumor Effects of PP2A Inhibitor LB100 in the Nervous System Cancers PP2A LB100 nervous system tumor biology brain tumor preclinical |
| title | Review of PP2A Tumor Biology and Antitumor Effects of PP2A Inhibitor LB100 in the Nervous System |
| title_full | Review of PP2A Tumor Biology and Antitumor Effects of PP2A Inhibitor LB100 in the Nervous System |
| title_fullStr | Review of PP2A Tumor Biology and Antitumor Effects of PP2A Inhibitor LB100 in the Nervous System |
| title_full_unstemmed | Review of PP2A Tumor Biology and Antitumor Effects of PP2A Inhibitor LB100 in the Nervous System |
| title_short | Review of PP2A Tumor Biology and Antitumor Effects of PP2A Inhibitor LB100 in the Nervous System |
| title_sort | review of pp2a tumor biology and antitumor effects of pp2a inhibitor lb100 in the nervous system |
| topic | PP2A LB100 nervous system tumor biology brain tumor preclinical |
| url | https://www.mdpi.com/2072-6694/13/12/3087 |
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