Risk of cardiovascular events in patients with metabolic syndrome: Results of a population-based prospective cohort study (PURE Turkey)
Objective: Metabolic syndrome (MetS) includes several cardiovascular (CV) risk factors. This study aimed to assess CV risk of MetS, contribution of its components to the risk, and whether MetS provides additional risk beyond its components. Methods: The Prospective Urban Rural Epidemiology (PURE) Tu...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
KARE Publishing
2020-08-01
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| Series: | Anatolian Journal of Cardiology |
| Subjects: | |
| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=anatoljcardiol&un=AJC-27227 |
| _version_ | 1797907038664130560 |
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| author | Aytekin Oğuz Mustafa Kılıçkap Sadi Güleç Yüksel Altuntaş Kubilay Karşıdağ Ahmet Temizhan Burcu Çalık Tümerdem Miraç Vural Keskinler Sumathy Rangarajan Salim Yusuf |
| author_facet | Aytekin Oğuz Mustafa Kılıçkap Sadi Güleç Yüksel Altuntaş Kubilay Karşıdağ Ahmet Temizhan Burcu Çalık Tümerdem Miraç Vural Keskinler Sumathy Rangarajan Salim Yusuf |
| author_sort | Aytekin Oğuz |
| collection | DOAJ |
| description | Objective: Metabolic syndrome (MetS) includes several cardiovascular (CV) risk factors. This study aimed to assess CV risk of MetS, contribution of its components to the risk, and whether MetS provides additional risk beyond its components.
Methods: The Prospective Urban Rural Epidemiology (PURE) Turkey cohort included 3933 individuals aged between 35 and 70 years, with a median follow-up of 8.9 years. MetS was diagnosed as the presence of any of the following criteria: high blood pressure, high fasting plasma glucose, abdominal obesity, low HDL-cholesterol, or high triglycerides. The primary outcome was the composite of fatal CV events, non-fatal myocardial infarction, stroke or heart failure, adjusted for age, sex, smoking, family history of CV diseases, and LDL-cholesterol.
Results: The primary outcome was more common in the MetS group [178 (9.2%) vs. 70 (3.5%); corresponding incidence rate of 11.3 vs. 4.2 per 1000 person-years; log-rank p<0.001]. Each component was significantly associated with the primary outcome; however, when the components were sequentially included in the model, abdominal obesity and high triglycerides did not provide additional risk on top of the other three components. The hazard ratio for MetS for the primary outcome was 2.12 (95% confidence interval 1.59–2.81, p<0.001), and the discriminative ability (c-statistics) of the models with MetS and the components was similar.
Conclusion: MetS increases the risk of CV events more than two-fold. High blood pressure, high fasting plasma glucose, and low HDL-cholesterol are the top three components of MetS for CV risk. MetS and its components have a similar discriminative ability for CV events. |
| first_indexed | 2024-04-10T10:30:19Z |
| format | Article |
| id | doaj.art-c2520ed9069d44dcb83e444ac2f61c3b |
| institution | Directory Open Access Journal |
| issn | 2149-2263 |
| language | English |
| last_indexed | 2024-04-10T10:30:19Z |
| publishDate | 2020-08-01 |
| publisher | KARE Publishing |
| record_format | Article |
| series | Anatolian Journal of Cardiology |
| spelling | doaj.art-c2520ed9069d44dcb83e444ac2f61c3b2023-02-15T16:21:10ZengKARE PublishingAnatolian Journal of Cardiology2149-22632020-08-0124319220010.14744/AnatolJCardiol.2020.27227AJC-27227Risk of cardiovascular events in patients with metabolic syndrome: Results of a population-based prospective cohort study (PURE Turkey)Aytekin Oğuz0Mustafa Kılıçkap1Sadi Güleç2Yüksel Altuntaş3Kubilay Karşıdağ4Ahmet Temizhan5Burcu Çalık Tümerdem6Miraç Vural Keskinler7Sumathy Rangarajan8Salim Yusuf9Department of Internal Medicine, Faculty of Medicine, İstanbul Medeniyet University; İstanbul-TurkeyDepartment of Cardiology, Faculty of Medicine, Ankara University; Ankara-TurkeyDepartment of Cardiology, Faculty of Medicine, Ankara University; Ankara-TurkeyClinic of Endocrinology and Metabolism, Faculty of Medicine, University of Health Sciences, İstanbul Şişli Hamidiye Etfal Health Training and Research Hospital; İstanbul-TurkeyDepartment of Internal Medicine, Division of Endocrinology, Faculty of Medicine, İstanbul University; İstanbul-TurkeyClinic of Cardiology, University of Health Science, Ankara City Hospital; Ankara-TurkeyDepartment of Health Administration, Marmara University Faculty of Health Sciences; İstanbul-TurkeyDepartment of Internal Medicine, Faculty of Medicine, İstanbul Medeniyet University; İstanbul-TurkeyPopulation Health Research Institute, McMaster University and Hamilton Health Sciences; Hamilton, ON-CanadaPopulation Health Research Institute, McMaster University and Hamilton Health Sciences; Hamilton, ON-CanadaObjective: Metabolic syndrome (MetS) includes several cardiovascular (CV) risk factors. This study aimed to assess CV risk of MetS, contribution of its components to the risk, and whether MetS provides additional risk beyond its components. Methods: The Prospective Urban Rural Epidemiology (PURE) Turkey cohort included 3933 individuals aged between 35 and 70 years, with a median follow-up of 8.9 years. MetS was diagnosed as the presence of any of the following criteria: high blood pressure, high fasting plasma glucose, abdominal obesity, low HDL-cholesterol, or high triglycerides. The primary outcome was the composite of fatal CV events, non-fatal myocardial infarction, stroke or heart failure, adjusted for age, sex, smoking, family history of CV diseases, and LDL-cholesterol. Results: The primary outcome was more common in the MetS group [178 (9.2%) vs. 70 (3.5%); corresponding incidence rate of 11.3 vs. 4.2 per 1000 person-years; log-rank p<0.001]. Each component was significantly associated with the primary outcome; however, when the components were sequentially included in the model, abdominal obesity and high triglycerides did not provide additional risk on top of the other three components. The hazard ratio for MetS for the primary outcome was 2.12 (95% confidence interval 1.59–2.81, p<0.001), and the discriminative ability (c-statistics) of the models with MetS and the components was similar. Conclusion: MetS increases the risk of CV events more than two-fold. High blood pressure, high fasting plasma glucose, and low HDL-cholesterol are the top three components of MetS for CV risk. MetS and its components have a similar discriminative ability for CV events.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=anatoljcardiol&un=AJC-27227metabolic syndromecardiovascular diseasesmortalitycohort study |
| spellingShingle | Aytekin Oğuz Mustafa Kılıçkap Sadi Güleç Yüksel Altuntaş Kubilay Karşıdağ Ahmet Temizhan Burcu Çalık Tümerdem Miraç Vural Keskinler Sumathy Rangarajan Salim Yusuf Risk of cardiovascular events in patients with metabolic syndrome: Results of a population-based prospective cohort study (PURE Turkey) Anatolian Journal of Cardiology metabolic syndrome cardiovascular diseases mortality cohort study |
| title | Risk of cardiovascular events in patients with metabolic syndrome: Results of a population-based prospective cohort study (PURE Turkey) |
| title_full | Risk of cardiovascular events in patients with metabolic syndrome: Results of a population-based prospective cohort study (PURE Turkey) |
| title_fullStr | Risk of cardiovascular events in patients with metabolic syndrome: Results of a population-based prospective cohort study (PURE Turkey) |
| title_full_unstemmed | Risk of cardiovascular events in patients with metabolic syndrome: Results of a population-based prospective cohort study (PURE Turkey) |
| title_short | Risk of cardiovascular events in patients with metabolic syndrome: Results of a population-based prospective cohort study (PURE Turkey) |
| title_sort | risk of cardiovascular events in patients with metabolic syndrome results of a population based prospective cohort study pure turkey |
| topic | metabolic syndrome cardiovascular diseases mortality cohort study |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=anatoljcardiol&un=AJC-27227 |
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