Novel Biphenyl Amines Inhibit Oestrogen Receptor (ER)-α in ER-Positive Mammary Carcinoma Cells

Novel Biphenyl Amines Inhibit Oestrogen Receptor (ER)-α in ER-Positive Mammary Carcinoma Cells

Herein, the activity of adamantanyl-tethered-biphenyl amines (ATBAs) as oestrogen receptor alpha (ERα) modulating ligands is reported. Using an ERα competitor assay it was demonstrated that ATBA compound 3-(adamantan-1-yl)-4-methoxy-N-(4-(trifluoromethyl) phenyl) aniline (AMTA) exhibited an inhibito...

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Bibliographic Details
Main Authors: Basappa Basappa, Baburajeev Chumadathil Pookunoth, Mamatha Shinduvalli Kempasiddegowda, Rangappa Knchugarakoppal Subbegowda, Peter E. Lobie, Vijay Pandey
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Molecules
Subjects:
arylamination
ERα ligands
human breast cancer cells
oestradiol
adamantane
Online Access:https://www.mdpi.com/1420-3049/26/4/783

Internet

https://www.mdpi.com/1420-3049/26/4/783

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