Energy Deposition around Swift Carbon-Ion Tracks in Liquid Water
Energetic carbon ions are promising projectiles used for cancer radiotherapy. A thorough knowledge of how the energy of these ions is deposited in biological media (mainly composed of liquid water) is required. This can be attained by means of detailed computer simulations, both macroscopically (rel...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-05-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/11/6121 |
| _version_ | 1797493125922422784 |
|---|---|
| author | Pablo de Vera Simone Taioli Paolo E. Trevisanutto Maurizio Dapor Isabel Abril Stefano Simonucci Rafael Garcia-Molina |
| author_facet | Pablo de Vera Simone Taioli Paolo E. Trevisanutto Maurizio Dapor Isabel Abril Stefano Simonucci Rafael Garcia-Molina |
| author_sort | Pablo de Vera |
| collection | DOAJ |
| description | Energetic carbon ions are promising projectiles used for cancer radiotherapy. A thorough knowledge of how the energy of these ions is deposited in biological media (mainly composed of liquid water) is required. This can be attained by means of detailed computer simulations, both macroscopically (relevant for appropriately delivering the dose) and at the nanoscale (important for determining the inflicted radiobiological damage). The energy lost per unit path length (i.e., the so-called stopping power) of carbon ions is here theoretically calculated within the dielectric formalism from the excitation spectrum of liquid water obtained from two complementary approaches (one relying on an optical-data model and the other exclusively on <i>ab initio</i> calculations). In addition, the energy carried at the nanometre scale by the generated secondary electrons around the ion’s path is simulated by means of a detailed Monte Carlo code. For this purpose, we use the ion and electron cross sections calculated by means of state-of-the art approaches suited to take into account the condensed-phase nature of the liquid water target. As a result of these simulations, the radial dose around the ion’s path is obtained, as well as the distributions of clustered events in nanometric volumes similar to the dimensions of DNA convolutions, contributing to the biological damage for carbon ions in a wide energy range, covering from the plateau to the maximum of the Bragg peak. |
| first_indexed | 2024-03-10T01:15:32Z |
| format | Article |
| id | doaj.art-c25423538a5e4396b6ef8c869bdaf5e5 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T01:15:32Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-c25423538a5e4396b6ef8c869bdaf5e52023-11-23T14:09:56ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-05-012311612110.3390/ijms23116121Energy Deposition around Swift Carbon-Ion Tracks in Liquid WaterPablo de Vera0Simone Taioli1Paolo E. Trevisanutto2Maurizio Dapor3Isabel Abril4Stefano Simonucci5Rafael Garcia-Molina6Departamento de Física, Centro de Investigación en Óptica y Nanofísica, Universidad de Murcia, 30100 Murcia, SpainEuropean Centre for Theoretical Studies in Nuclear Physics and Related Areas (ECT*), Bruno Kessler Foundation, 38123 Povo, ItalyDipartimento di Ingegneria, Unità di Ricerca di Fisica non Lineare e Modelli Matematici, Università Campus Bio-Medico, Via Alvaro del Portillo 21, 00154 Roma, ItalyEuropean Centre for Theoretical Studies in Nuclear Physics and Related Areas (ECT*), Bruno Kessler Foundation, 38123 Povo, ItalyDepartament de Física Aplicada, Universitat d’Alacant, 03690 San Vicente del Raspeig, SpainDivision of Physics, School of Science and Technology, Università di Camerino and INFN Sezione di Perugia, 06123 Perugia, ItalyDepartamento de Física, Centro de Investigación en Óptica y Nanofísica, Universidad de Murcia, 30100 Murcia, SpainEnergetic carbon ions are promising projectiles used for cancer radiotherapy. A thorough knowledge of how the energy of these ions is deposited in biological media (mainly composed of liquid water) is required. This can be attained by means of detailed computer simulations, both macroscopically (relevant for appropriately delivering the dose) and at the nanoscale (important for determining the inflicted radiobiological damage). The energy lost per unit path length (i.e., the so-called stopping power) of carbon ions is here theoretically calculated within the dielectric formalism from the excitation spectrum of liquid water obtained from two complementary approaches (one relying on an optical-data model and the other exclusively on <i>ab initio</i> calculations). In addition, the energy carried at the nanometre scale by the generated secondary electrons around the ion’s path is simulated by means of a detailed Monte Carlo code. For this purpose, we use the ion and electron cross sections calculated by means of state-of-the art approaches suited to take into account the condensed-phase nature of the liquid water target. As a result of these simulations, the radial dose around the ion’s path is obtained, as well as the distributions of clustered events in nanometric volumes similar to the dimensions of DNA convolutions, contributing to the biological damage for carbon ions in a wide energy range, covering from the plateau to the maximum of the Bragg peak.https://www.mdpi.com/1422-0067/23/11/6121carbon ion beamshadrontherapynanoscale biodamageliquid waterMonte Carlo simulationscattering cross sections in the condensed phase |
| spellingShingle | Pablo de Vera Simone Taioli Paolo E. Trevisanutto Maurizio Dapor Isabel Abril Stefano Simonucci Rafael Garcia-Molina Energy Deposition around Swift Carbon-Ion Tracks in Liquid Water International Journal of Molecular Sciences carbon ion beams hadrontherapy nanoscale biodamage liquid water Monte Carlo simulation scattering cross sections in the condensed phase |
| title | Energy Deposition around Swift Carbon-Ion Tracks in Liquid Water |
| title_full | Energy Deposition around Swift Carbon-Ion Tracks in Liquid Water |
| title_fullStr | Energy Deposition around Swift Carbon-Ion Tracks in Liquid Water |
| title_full_unstemmed | Energy Deposition around Swift Carbon-Ion Tracks in Liquid Water |
| title_short | Energy Deposition around Swift Carbon-Ion Tracks in Liquid Water |
| title_sort | energy deposition around swift carbon ion tracks in liquid water |
| topic | carbon ion beams hadrontherapy nanoscale biodamage liquid water Monte Carlo simulation scattering cross sections in the condensed phase |
| url | https://www.mdpi.com/1422-0067/23/11/6121 |
| work_keys_str_mv | AT pablodevera energydepositionaroundswiftcarboniontracksinliquidwater AT simonetaioli energydepositionaroundswiftcarboniontracksinliquidwater AT paoloetrevisanutto energydepositionaroundswiftcarboniontracksinliquidwater AT mauriziodapor energydepositionaroundswiftcarboniontracksinliquidwater AT isabelabril energydepositionaroundswiftcarboniontracksinliquidwater AT stefanosimonucci energydepositionaroundswiftcarboniontracksinliquidwater AT rafaelgarciamolina energydepositionaroundswiftcarboniontracksinliquidwater |