Tumor Multifocality is a Significant Risk Factor of Urinary Bladder Recurrence after Nephroureterectomy in Patients with Upper Tract Urothelial Carcinoma: A Single-Institutional Study
The purpose of this study was to identify the significant risk factors of urinary bladder recurrence (UBR) after nephroureterectomy (NUx) in patients with upper tract urothelial carcinoma (UTUC). A total of 550 patients diagnosed with UTUC between January 2001 and December 2015 were included in this...
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| Format: | Article |
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MDPI AG
2020-04-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/10/4/201 |
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| author | Chuan-Shu Chen Jian-Ri Li Shian-Shiang Wang Cheng-Kuang Yang Chen-Li Cheng Chi-Rei Yang Yen-Chuan Ou Hao-Chung Ho Chia-Yen Lin Sheng-Chun Hung Cheng-Che Chen Shu-Chi Wang Kun-Yuan Chiu Shun-Fa Yang |
| author_facet | Chuan-Shu Chen Jian-Ri Li Shian-Shiang Wang Cheng-Kuang Yang Chen-Li Cheng Chi-Rei Yang Yen-Chuan Ou Hao-Chung Ho Chia-Yen Lin Sheng-Chun Hung Cheng-Che Chen Shu-Chi Wang Kun-Yuan Chiu Shun-Fa Yang |
| author_sort | Chuan-Shu Chen |
| collection | DOAJ |
| description | The purpose of this study was to identify the significant risk factors of urinary bladder recurrence (UBR) after nephroureterectomy (NUx) in patients with upper tract urothelial carcinoma (UTUC). A total of 550 patients diagnosed with UTUC between January 2001 and December 2015 were included in this retrospective study. The median age of our patients was 68 (range 24–93) and the median follow-up time after NUx was 40.3 months (range 8–191). The most important censored point of this study was the first episode of UBR. Of the 550 patients, UBR occurred in 164 patients (29.8%). One hundred and forty-two (86.6%) patients with UBR were identified within two years after NUx for UTUC, with the median time interval between NUx and UBR being 8.4 months (range 3–59.8). Through univariate analysis, the positive surgical margin (<i>p</i> = 0.049) and tumor multifocality (<i>p</i> = 0.024) were both significant prognostic factors for UBR-free survival after NUx in patients with UTUC. However, only tumor multifocality (<i>p</i> = 0.037) remained a significant prognostic factor by multivariate analysis. In conclusion, tumor multifocality is a significant risk factor of UBR after nephroureterectomy in patients with upper tract urothelial carcinoma. |
| first_indexed | 2024-03-10T20:42:21Z |
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| id | doaj.art-c25988e6609b46128cd01cc715e4a514 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T20:42:21Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-c25988e6609b46128cd01cc715e4a5142023-11-19T20:38:23ZengMDPI AGDiagnostics2075-44182020-04-0110420110.3390/diagnostics10040201Tumor Multifocality is a Significant Risk Factor of Urinary Bladder Recurrence after Nephroureterectomy in Patients with Upper Tract Urothelial Carcinoma: A Single-Institutional StudyChuan-Shu Chen0Jian-Ri Li1Shian-Shiang Wang2Cheng-Kuang Yang3Chen-Li Cheng4Chi-Rei Yang5Yen-Chuan Ou6Hao-Chung Ho7Chia-Yen Lin8Sheng-Chun Hung9Cheng-Che Chen10Shu-Chi Wang11Kun-Yuan Chiu12Shun-Fa Yang13Institute of Medicine, Chung Shan Medical University, Taichung 402, TaiwanInstitute of Medicine, Chung Shan Medical University, Taichung 402, TaiwanInstitute of Medicine, Chung Shan Medical University, Taichung 402, TaiwanDivision of Urology, Department of Surgery, Taichung Veterans General Hospital, Taichung 407, TaiwanInstitute of Medicine, Chung Shan Medical University, Taichung 402, TaiwanDepartment of Urology, China Medical University Hospital, Taichung 404, TaiwanDepartment of Urology, Tung’s Taichung MetroHarbor Hospital, Taichung 433, TaiwanDivision of Urology, Department of Surgery, Taichung Veterans General Hospital, Taichung 407, TaiwanInstitute of Medicine, Chung Shan Medical University, Taichung 402, TaiwanInstitute of Medicine, Chung Shan Medical University, Taichung 402, TaiwanDivision of Urology, Department of Surgery, Taichung Veterans General Hospital, Taichung 407, TaiwanDivision of Urology, Department of Surgery, Taichung Veterans General Hospital, Taichung 407, TaiwanDivision of Urology, Department of Surgery, Taichung Veterans General Hospital, Taichung 407, TaiwanInstitute of Medicine, Chung Shan Medical University, Taichung 402, TaiwanThe purpose of this study was to identify the significant risk factors of urinary bladder recurrence (UBR) after nephroureterectomy (NUx) in patients with upper tract urothelial carcinoma (UTUC). A total of 550 patients diagnosed with UTUC between January 2001 and December 2015 were included in this retrospective study. The median age of our patients was 68 (range 24–93) and the median follow-up time after NUx was 40.3 months (range 8–191). The most important censored point of this study was the first episode of UBR. Of the 550 patients, UBR occurred in 164 patients (29.8%). One hundred and forty-two (86.6%) patients with UBR were identified within two years after NUx for UTUC, with the median time interval between NUx and UBR being 8.4 months (range 3–59.8). Through univariate analysis, the positive surgical margin (<i>p</i> = 0.049) and tumor multifocality (<i>p</i> = 0.024) were both significant prognostic factors for UBR-free survival after NUx in patients with UTUC. However, only tumor multifocality (<i>p</i> = 0.037) remained a significant prognostic factor by multivariate analysis. In conclusion, tumor multifocality is a significant risk factor of UBR after nephroureterectomy in patients with upper tract urothelial carcinoma.https://www.mdpi.com/2075-4418/10/4/201urinary bladderrecurrencenephroureterectomyupper tract urothelial carcinomatumor multifocality |
| spellingShingle | Chuan-Shu Chen Jian-Ri Li Shian-Shiang Wang Cheng-Kuang Yang Chen-Li Cheng Chi-Rei Yang Yen-Chuan Ou Hao-Chung Ho Chia-Yen Lin Sheng-Chun Hung Cheng-Che Chen Shu-Chi Wang Kun-Yuan Chiu Shun-Fa Yang Tumor Multifocality is a Significant Risk Factor of Urinary Bladder Recurrence after Nephroureterectomy in Patients with Upper Tract Urothelial Carcinoma: A Single-Institutional Study Diagnostics urinary bladder recurrence nephroureterectomy upper tract urothelial carcinoma tumor multifocality |
| title | Tumor Multifocality is a Significant Risk Factor of Urinary Bladder Recurrence after Nephroureterectomy in Patients with Upper Tract Urothelial Carcinoma: A Single-Institutional Study |
| title_full | Tumor Multifocality is a Significant Risk Factor of Urinary Bladder Recurrence after Nephroureterectomy in Patients with Upper Tract Urothelial Carcinoma: A Single-Institutional Study |
| title_fullStr | Tumor Multifocality is a Significant Risk Factor of Urinary Bladder Recurrence after Nephroureterectomy in Patients with Upper Tract Urothelial Carcinoma: A Single-Institutional Study |
| title_full_unstemmed | Tumor Multifocality is a Significant Risk Factor of Urinary Bladder Recurrence after Nephroureterectomy in Patients with Upper Tract Urothelial Carcinoma: A Single-Institutional Study |
| title_short | Tumor Multifocality is a Significant Risk Factor of Urinary Bladder Recurrence after Nephroureterectomy in Patients with Upper Tract Urothelial Carcinoma: A Single-Institutional Study |
| title_sort | tumor multifocality is a significant risk factor of urinary bladder recurrence after nephroureterectomy in patients with upper tract urothelial carcinoma a single institutional study |
| topic | urinary bladder recurrence nephroureterectomy upper tract urothelial carcinoma tumor multifocality |
| url | https://www.mdpi.com/2075-4418/10/4/201 |
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