Efficacy of probiotic Streptococcus thermophilus in counteracting TGF-β1-induced fibrotic response in normal human dermal fibroblasts

Efficacy of probiotic Streptococcus thermophilus in counteracting TGF-β1-induced fibrotic response in normal human dermal fibroblasts

Abstract Background Abnormal and deregulated skin wound healing associated with prolonged inflammation may result in dermal fibrosis. Since the current therapeutic strategies revealed unsatisfactory, the investigation of alternative approaches such as those based on the use of specific probiotic str...

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Bibliographic Details
Main Authors: Francesca Lombardi, Francesca Rosaria Augello, Serena Artone, Blerina Bahiti, Jenna Marie Sheldon, Maurizio Giuliani, Maria Grazia Cifone, Paola Palumbo, Benedetta Cinque
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Journal of Inflammation
Subjects:
Skin fibrosis
TGF-β1
S. thermophilus
Fibrotic markers
Smad signaling
β-catenin
Online Access:https://doi.org/10.1186/s12950-022-00324-9

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