Silencing of PGK1 Promotes Sensitivity to Paclitaxel Treatment by Upregulating XAF1-Mediated Apoptosis in Triple-Negative Breast Cancer

Silencing of PGK1 Promotes Sensitivity to Paclitaxel Treatment by Upregulating XAF1-Mediated Apoptosis in Triple-Negative Breast Cancer

Objective: Triple negative breast cancer (TNBC) is known to have aggressive clinical course and a high risk of recurrence. Given the lack of effective targeted therapy options, paclitaxel-based chemotherapy is still the primary option for TNBC patients. However, patients who fail to achieve a comple...

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Bibliographic Details
Main Authors: Shanshan Sun, Hao Wu, Xiaohong Wu, Zilong You, Yang Jiang, Xiaoshuan Liang, Zhuo Chen, Ye Zhang, Wei Wei, Yongdong Jiang, Yanbo Chen, Yanni Song, Da Pang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Oncology
Subjects:
PGK1
triple-negative breast cancer
paclitaxel
sensitivity
chemotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.535230/full

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