Acute peripancreatic fluid collection in acute pancreatitis: Incidence, outcome, and association with inflammatory markers
Background: The hospital outcomes and predictors of acute peripancreatic fluid collection (APFC) have not been well-characterized. In this study, we aimed to investigate the clinical outcomes of APFC in patients with acute pancreatitis (AP) and the role of the systemic immune-inflammation index (SII...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | The Saudi Journal of Gastroenterology |
| Subjects: | |
| Online Access: | http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2023;volume=29;issue=4;spage=225;epage=232;aulast= |
| _version_ | 1797738481802280960 |
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| author | Tevfik Solakoglu Nurten Turkel Kucukmetin Mustafa Akar Hüseyin Koseoglu |
| author_facet | Tevfik Solakoglu Nurten Turkel Kucukmetin Mustafa Akar Hüseyin Koseoglu |
| author_sort | Tevfik Solakoglu |
| collection | DOAJ |
| description | Background: The hospital outcomes and predictors of acute peripancreatic fluid collection (APFC) have not been well-characterized. In this study, we aimed to investigate the clinical outcomes of APFC in patients with acute pancreatitis (AP) and the role of the systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), and C-reactive protein (CRP) level in predicting the occurrence of APFC.
Methods: In this retrospective study, the complicated group (patients with APFC) and the uncomplicated group (patients without APFC) were compared for their clinical characteristics, hospital outcomes (mortality rate, intensive care unit admission rate, and length of hospital stay), pseudocyst formation, CRP levels, SII, and SIRI on admission and at 48 hours.
Results: Of 132 patients with AP, 51 (38.6%) had APFC and eight (6.1%) had pancreatic pseudocysts. Of 51 patients with APFC, 15.7% had pancreatic pseudocysts. Pseudocyst did not develop in the uncomplicated group. SII value at 48 h [median 859 (541–1740) x 109/L vs. 610 (343–1259) x 109/L, P = 0.01] and CRP level at 48 h [89 (40–237) mg/L vs. 38 (12–122) mg/L, P = 0.01] were higher in the complicated group than in the uncomplicated group. The length of hospital stay was longer in the complicated group, compared with the uncomplicated group [median 8 days (5–15), vs. 4 days (3–7), P < 0.001, respectively]. No significant difference was detected between the two study groups' mortality rates and intensive care unit admission rates.
Conclusions: While 38.6% of the AP patients had APFC, 6.1% of all patients and 15.7% of the patients with APFC had pancreatic pseudocysts. APFC was found to lengthen the hospital stay and to be associated with the SII value and CRP level measured at 48 h. |
| first_indexed | 2024-03-12T13:43:28Z |
| format | Article |
| id | doaj.art-c25b43cde29d4f578871b93ea2b7c19d |
| institution | Directory Open Access Journal |
| issn | 1319-3767 1998-4049 |
| language | English |
| last_indexed | 2024-03-12T13:43:28Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | The Saudi Journal of Gastroenterology |
| spelling | doaj.art-c25b43cde29d4f578871b93ea2b7c19d2023-08-23T09:49:10ZengWolters Kluwer Medknow PublicationsThe Saudi Journal of Gastroenterology1319-37671998-40492023-01-0129422523210.4103/sjg.sjg_443_22Acute peripancreatic fluid collection in acute pancreatitis: Incidence, outcome, and association with inflammatory markersTevfik SolakogluNurten Turkel KucukmetinMustafa AkarHüseyin KoseogluBackground: The hospital outcomes and predictors of acute peripancreatic fluid collection (APFC) have not been well-characterized. In this study, we aimed to investigate the clinical outcomes of APFC in patients with acute pancreatitis (AP) and the role of the systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), and C-reactive protein (CRP) level in predicting the occurrence of APFC. Methods: In this retrospective study, the complicated group (patients with APFC) and the uncomplicated group (patients without APFC) were compared for their clinical characteristics, hospital outcomes (mortality rate, intensive care unit admission rate, and length of hospital stay), pseudocyst formation, CRP levels, SII, and SIRI on admission and at 48 hours. Results: Of 132 patients with AP, 51 (38.6%) had APFC and eight (6.1%) had pancreatic pseudocysts. Of 51 patients with APFC, 15.7% had pancreatic pseudocysts. Pseudocyst did not develop in the uncomplicated group. SII value at 48 h [median 859 (541–1740) x 109/L vs. 610 (343–1259) x 109/L, P = 0.01] and CRP level at 48 h [89 (40–237) mg/L vs. 38 (12–122) mg/L, P = 0.01] were higher in the complicated group than in the uncomplicated group. The length of hospital stay was longer in the complicated group, compared with the uncomplicated group [median 8 days (5–15), vs. 4 days (3–7), P < 0.001, respectively]. No significant difference was detected between the two study groups' mortality rates and intensive care unit admission rates. Conclusions: While 38.6% of the AP patients had APFC, 6.1% of all patients and 15.7% of the patients with APFC had pancreatic pseudocysts. APFC was found to lengthen the hospital stay and to be associated with the SII value and CRP level measured at 48 h.http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2023;volume=29;issue=4;spage=225;epage=232;aulast=acute pancreatitisc-reactive proteinperipancreatic fluid collectionsystemic immune-inflammation index |
| spellingShingle | Tevfik Solakoglu Nurten Turkel Kucukmetin Mustafa Akar Hüseyin Koseoglu Acute peripancreatic fluid collection in acute pancreatitis: Incidence, outcome, and association with inflammatory markers The Saudi Journal of Gastroenterology acute pancreatitis c-reactive protein peripancreatic fluid collection systemic immune-inflammation index |
| title | Acute peripancreatic fluid collection in acute pancreatitis: Incidence, outcome, and association with inflammatory markers |
| title_full | Acute peripancreatic fluid collection in acute pancreatitis: Incidence, outcome, and association with inflammatory markers |
| title_fullStr | Acute peripancreatic fluid collection in acute pancreatitis: Incidence, outcome, and association with inflammatory markers |
| title_full_unstemmed | Acute peripancreatic fluid collection in acute pancreatitis: Incidence, outcome, and association with inflammatory markers |
| title_short | Acute peripancreatic fluid collection in acute pancreatitis: Incidence, outcome, and association with inflammatory markers |
| title_sort | acute peripancreatic fluid collection in acute pancreatitis incidence outcome and association with inflammatory markers |
| topic | acute pancreatitis c-reactive protein peripancreatic fluid collection systemic immune-inflammation index |
| url | http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2023;volume=29;issue=4;spage=225;epage=232;aulast= |
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