The value of adjacent vessel sign in malignant breast tumors
PURPOSEThe aim of this study was to evaluate the prognostic quality of adjacent vessel sign (AVS) in malignant breast tumors by comparing it with classical prognostic pathological biomarkers and magnetic resonance imaging (MRI) findings.METHODSA total of 124 patients with 133 malignant lesions were...
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2022-09-01
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| Series: | Diagnostic and Interventional Radiology |
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http://www.dirjournal.org/archives/archive-detail/article-preview/the-value-of-adjacent-vessel-sign-in-malignant-bre/53621
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| _version_ | 1797691381289844736 |
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| author | Ezra Çetinkaya Şeyma Yıldız Hafize Otçu Rasul Sharifov Fatma Çelik Yabul Alpay Alkan |
| author_facet | Ezra Çetinkaya Şeyma Yıldız Hafize Otçu Rasul Sharifov Fatma Çelik Yabul Alpay Alkan |
| author_sort | Ezra Çetinkaya |
| collection | DOAJ |
| description | PURPOSEThe aim of this study was to evaluate the prognostic quality of adjacent vessel sign (AVS) in malignant breast tumors by comparing it with classical prognostic pathological biomarkers and magnetic resonance imaging (MRI) findings.METHODSA total of 124 patients with 133 malignant lesions were included. All the imaging was performed on a 1.5T Avanto scanner and the images were interpreted according to BI-RADS-MR® (fifth ed.) atlas. Maximum intensity projection (MIP) images were constructed from subtracted post-contrast images and were used to investigate AVS. Histopathological results and MRI findings were compared with AVS.RESULTSInterobserver agreement about AVS status was substantial (κ=0.64). AVS positive lesions were significantly bigger in size (P < .001, AVS negative: median 12 mm, AVS positive: median 31 mm). AVS was significantly associated with increased Ki-67 index and axillary lymph node metastasis (P=.009 and P=.019, respectively). Between AVS and lymphovascular invasion (LVI), there was a trend toward positive relationship (P=.076). MRI findings of T2 hypointensity, peritumoral edema, irregular shape, non-homogeneous contrast enhancement, rapid early contrast enhancement, and skin infiltration showed significant positive relation with AVS (P < .001, P < .001, P < .001, P=.02, P=.021, and P=.021, respectively). AVS is found to be associated with increased Ki-67 index, axillary lymph node metastasis, and some MRI findings that point to malignancy or poor prognosis.CONCLUSIONAVS indicates poor prognosis since it is related to axillary lymph node metastasis, increased Ki-67 index, LVI, peritumoral edema, rapid early contrast enhancement, increased background enhancement, skin extension, T2 hypointensity, non-homogeneous contrast enhancement, irregular lesion shape, and larger tumor size. AVS is an easy to use sign that shows substantial interobserver agreement. |
| first_indexed | 2024-03-12T02:13:28Z |
| format | Article |
| id | doaj.art-c25b52986c814d9bb5affeffee6fb95b |
| institution | Directory Open Access Journal |
| issn | 1305-3825 1305-3612 |
| language | English |
| last_indexed | 2024-03-12T02:13:28Z |
| publishDate | 2022-09-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Diagnostic and Interventional Radiology |
| spelling | doaj.art-c25b52986c814d9bb5affeffee6fb95b2023-09-06T12:05:45ZengGalenos Publishing HouseDiagnostic and Interventional Radiology1305-38251305-36122022-09-0128546346910.5152/dir.2022.21122813049054The value of adjacent vessel sign in malignant breast tumorsEzra Çetinkaya0Şeyma Yıldız1Hafize Otçu2Rasul Sharifov3Fatma Çelik Yabul4Alpay Alkan5 Department of Radiology, 25 Aralık State Hospital, Gaziantep, Turkey Department of Radiology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey Department of Radiology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey Department of Radiology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey Department of Radiology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey Department of Radiology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey PURPOSEThe aim of this study was to evaluate the prognostic quality of adjacent vessel sign (AVS) in malignant breast tumors by comparing it with classical prognostic pathological biomarkers and magnetic resonance imaging (MRI) findings.METHODSA total of 124 patients with 133 malignant lesions were included. All the imaging was performed on a 1.5T Avanto scanner and the images were interpreted according to BI-RADS-MR® (fifth ed.) atlas. Maximum intensity projection (MIP) images were constructed from subtracted post-contrast images and were used to investigate AVS. Histopathological results and MRI findings were compared with AVS.RESULTSInterobserver agreement about AVS status was substantial (κ=0.64). AVS positive lesions were significantly bigger in size (P < .001, AVS negative: median 12 mm, AVS positive: median 31 mm). AVS was significantly associated with increased Ki-67 index and axillary lymph node metastasis (P=.009 and P=.019, respectively). Between AVS and lymphovascular invasion (LVI), there was a trend toward positive relationship (P=.076). MRI findings of T2 hypointensity, peritumoral edema, irregular shape, non-homogeneous contrast enhancement, rapid early contrast enhancement, and skin infiltration showed significant positive relation with AVS (P < .001, P < .001, P < .001, P=.02, P=.021, and P=.021, respectively). AVS is found to be associated with increased Ki-67 index, axillary lymph node metastasis, and some MRI findings that point to malignancy or poor prognosis.CONCLUSIONAVS indicates poor prognosis since it is related to axillary lymph node metastasis, increased Ki-67 index, LVI, peritumoral edema, rapid early contrast enhancement, increased background enhancement, skin extension, T2 hypointensity, non-homogeneous contrast enhancement, irregular lesion shape, and larger tumor size. AVS is an easy to use sign that shows substantial interobserver agreement. http://www.dirjournal.org/archives/archive-detail/article-preview/the-value-of-adjacent-vessel-sign-in-malignant-bre/53621 |
| spellingShingle | Ezra Çetinkaya Şeyma Yıldız Hafize Otçu Rasul Sharifov Fatma Çelik Yabul Alpay Alkan The value of adjacent vessel sign in malignant breast tumors Diagnostic and Interventional Radiology |
| title | The value of adjacent vessel sign in malignant breast tumors |
| title_full | The value of adjacent vessel sign in malignant breast tumors |
| title_fullStr | The value of adjacent vessel sign in malignant breast tumors |
| title_full_unstemmed | The value of adjacent vessel sign in malignant breast tumors |
| title_short | The value of adjacent vessel sign in malignant breast tumors |
| title_sort | value of adjacent vessel sign in malignant breast tumors |
| url |
http://www.dirjournal.org/archives/archive-detail/article-preview/the-value-of-adjacent-vessel-sign-in-malignant-bre/53621
|
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