Hepatic hemangioma: proportion and predictor of surgical treatment with emphasis on its growth rate
Background/Aims There are limited studies on the management of hepatic hemangiomas (HHs). We investigated the proportion and predictors of surgical resection and analyzed HH growth rates in addition to associated factors. Methods A retrospective case-control study of patients treated in 2 centers wa...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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The Korean Association of Internal Medicine
2023-11-01
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| Series: | The Korean Journal of Internal Medicine |
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| Online Access: | http://www.kjim.org/upload/kjim-2023-062.pdf |
| _version_ | 1797633962796908544 |
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| author | Young Cheol Shin Eun Ju Cho Hee Young Na Jai Young Cho Ho-Seong Han Yoon Jin Lee Haeryoung Kim Sangmi Jang Gwang Hyeon Choi Eun Sun Jang Jin-Wook Kim Sook-Hyang Jeong |
| author_facet | Young Cheol Shin Eun Ju Cho Hee Young Na Jai Young Cho Ho-Seong Han Yoon Jin Lee Haeryoung Kim Sangmi Jang Gwang Hyeon Choi Eun Sun Jang Jin-Wook Kim Sook-Hyang Jeong |
| author_sort | Young Cheol Shin |
| collection | DOAJ |
| description | Background/Aims There are limited studies on the management of hepatic hemangiomas (HHs). We investigated the proportion and predictors of surgical resection and analyzed HH growth rates in addition to associated factors. Methods A retrospective case-control study of patients treated in 2 centers was conducted. Thirty-six patients who underwent surgical resection were assigned to the case group. Patients who did not undergo surgical treatment were randomly selected at a 1:10 ratio and assigned to the control group (n = 360). Baseline characteristics, clinical course and surgical outcomes were analyzed. Results The proportion of surgically treated HH patients was 0.3% (36 per 11,049). The longest diameter at diagnosis (mean ± standard deviation) was 7.7 ± 5.2 cm in the case group and 2.4 ± 1.8 cm in the control group (p < 0.001). In the multivariate analysis, the presence of more than 2 HHs (odds ratio [OR] 7.64, 95% confidence interval [CI] 1.40–41.72) and a growth rate of more than 4.8%/year (OR 30.73, 95% CI 4.86–194.51) were independently associated with surgical treatment. Symptom development during follow-up was related to HH size > 10 cm (OR 10.50, 95% CI 1.06–103.77, p = 0.04). The subgroup analysis showed substantial growth in 41.3% with an overall mean annual growth rate of 0.14 cm. Conclusions Approximately one in 300 patients with an HH underwent surgical treatment. Multiple HHs and a growth rate of more than 4.8%/year were indications for surgical treatment. Nearly half of the HHs showed growing pattern in our study. |
| first_indexed | 2024-03-11T12:01:05Z |
| format | Article |
| id | doaj.art-c25bfbd9a30a49038cd060e87580c377 |
| institution | Directory Open Access Journal |
| issn | 1226-3303 2005-6648 |
| language | English |
| last_indexed | 2024-03-11T12:01:05Z |
| publishDate | 2023-11-01 |
| publisher | The Korean Association of Internal Medicine |
| record_format | Article |
| series | The Korean Journal of Internal Medicine |
| spelling | doaj.art-c25bfbd9a30a49038cd060e87580c3772023-11-08T05:34:55ZengThe Korean Association of Internal MedicineThe Korean Journal of Internal Medicine1226-33032005-66482023-11-0138681883010.3904/kjim.2023.062170850Hepatic hemangioma: proportion and predictor of surgical treatment with emphasis on its growth rateYoung Cheol Shin0Eun Ju Cho1Hee Young Na2Jai Young Cho3Ho-Seong Han4Yoon Jin Lee5Haeryoung Kim6Sangmi Jang7Gwang Hyeon Choi8Eun Sun Jang9Jin-Wook Kim10Sook-Hyang Jeong11 Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea Department of Internal Medicine and Liver Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea Department of Pathology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea Department of Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea Department of Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea Department of Radiology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea Department of Pathology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, KoreaBackground/Aims There are limited studies on the management of hepatic hemangiomas (HHs). We investigated the proportion and predictors of surgical resection and analyzed HH growth rates in addition to associated factors. Methods A retrospective case-control study of patients treated in 2 centers was conducted. Thirty-six patients who underwent surgical resection were assigned to the case group. Patients who did not undergo surgical treatment were randomly selected at a 1:10 ratio and assigned to the control group (n = 360). Baseline characteristics, clinical course and surgical outcomes were analyzed. Results The proportion of surgically treated HH patients was 0.3% (36 per 11,049). The longest diameter at diagnosis (mean ± standard deviation) was 7.7 ± 5.2 cm in the case group and 2.4 ± 1.8 cm in the control group (p < 0.001). In the multivariate analysis, the presence of more than 2 HHs (odds ratio [OR] 7.64, 95% confidence interval [CI] 1.40–41.72) and a growth rate of more than 4.8%/year (OR 30.73, 95% CI 4.86–194.51) were independently associated with surgical treatment. Symptom development during follow-up was related to HH size > 10 cm (OR 10.50, 95% CI 1.06–103.77, p = 0.04). The subgroup analysis showed substantial growth in 41.3% with an overall mean annual growth rate of 0.14 cm. Conclusions Approximately one in 300 patients with an HH underwent surgical treatment. Multiple HHs and a growth rate of more than 4.8%/year were indications for surgical treatment. Nearly half of the HHs showed growing pattern in our study.http://www.kjim.org/upload/kjim-2023-062.pdfhemangiomaliversurgeryarteriovenous malformation |
| spellingShingle | Young Cheol Shin Eun Ju Cho Hee Young Na Jai Young Cho Ho-Seong Han Yoon Jin Lee Haeryoung Kim Sangmi Jang Gwang Hyeon Choi Eun Sun Jang Jin-Wook Kim Sook-Hyang Jeong Hepatic hemangioma: proportion and predictor of surgical treatment with emphasis on its growth rate The Korean Journal of Internal Medicine hemangioma liver surgery arteriovenous malformation |
| title | Hepatic hemangioma: proportion and predictor of surgical treatment with emphasis on its growth rate |
| title_full | Hepatic hemangioma: proportion and predictor of surgical treatment with emphasis on its growth rate |
| title_fullStr | Hepatic hemangioma: proportion and predictor of surgical treatment with emphasis on its growth rate |
| title_full_unstemmed | Hepatic hemangioma: proportion and predictor of surgical treatment with emphasis on its growth rate |
| title_short | Hepatic hemangioma: proportion and predictor of surgical treatment with emphasis on its growth rate |
| title_sort | hepatic hemangioma proportion and predictor of surgical treatment with emphasis on its growth rate |
| topic | hemangioma liver surgery arteriovenous malformation |
| url | http://www.kjim.org/upload/kjim-2023-062.pdf |
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