Simultaneous Determination of Bufalin and Its Nine Metabolites in Rat Plasma for Characterization of Metabolic Profiles and Pharmacokinetic Study by LC–MS/MS

Simultaneous Determination of Bufalin and Its Nine Metabolites in Rat Plasma for Characterization of Metabolic Profiles and Pharmacokinetic Study by LC–MS/MS

Characterization and determination of metabolites to monitor metabolic pathways play a paramount role in evaluating the efficacy and safety of medicines. However, the separation and quantification of metabolites are rather difficult due to their limited contents in vivo, especially in the case of Ch...

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Bibliographic Details
Main Authors: Wenlong Wei, Yang Yu, Xia Wang, Linhui Yang, Hang Zhang, Hongjian Ji, Zhenwei Li, Jinjun Hou, Wanying Wu, Dean Guo
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Molecules
Subjects:
bufalin
metabolite
quantification
pharmacokinetics
Online Access:https://www.mdpi.com/1420-3049/24/9/1662

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