Intraluminal Thrombus Characteristics in AAA Patients: Non-Invasive Diagnosis Using CFD
Abdominal aortic aneurysms (AAA) continue to pose a high mortality risk despite advances in medical imaging and surgery. Intraluminal thrombus (ILT) is detected in most AAAs and may critically impact their development. Therefore, understanding ILT deposition and growth is of practical importance. To...
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MDPI AG
2023-04-01
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| Series: | Bioengineering |
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| Online Access: | https://www.mdpi.com/2306-5354/10/5/540 |
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| author | Djelloul Belkacemi Miloud Tahar Abbes Mohammad Al-Rawi Ahmed M. Al-Jumaily Sofiane Bachene Boualem Laribi |
| author_facet | Djelloul Belkacemi Miloud Tahar Abbes Mohammad Al-Rawi Ahmed M. Al-Jumaily Sofiane Bachene Boualem Laribi |
| author_sort | Djelloul Belkacemi |
| collection | DOAJ |
| description | Abdominal aortic aneurysms (AAA) continue to pose a high mortality risk despite advances in medical imaging and surgery. Intraluminal thrombus (ILT) is detected in most AAAs and may critically impact their development. Therefore, understanding ILT deposition and growth is of practical importance. To assist in managing these patients, the scientific community has been researching the relationship between intraluminal thrombus (ILT) and hemodynamic parameters wall shear stress (WSS) derivatives. This study analyzed three patient-specific AAA models reconstructed from CT scans using computational fluid dynamics (CFD) simulations and a pulsatile non-Newtonian blood flow model. The co-localization and relationship between WSS-based hemodynamic parameters and ILT deposition were examined. The results show that ILT tends to occur in regions of low velocity and time-averaged WSS (TAWSS) and high oscillation shear index (OSI), endothelial cell activation potential (ECAP), and relative residence time (RRT) values. ILT deposition areas were found in regions of low TAWSS and high OSI independently of the nature of flow near the wall characterized by transversal WSS (TransWSS). A new approach is suggested which is based on the estimation of CFD-based WSS indices specifically in the thinnest and thickest ILT areas of AAA patients; this approach is promising and supports the effectiveness of CFD as a decision-making tool for clinicians. Further research with a larger patient cohort and follow-up data are needed to confirm these findings. |
| first_indexed | 2024-03-11T03:57:03Z |
| format | Article |
| id | doaj.art-c25c477506b14461bf04bd8b64fdac67 |
| institution | Directory Open Access Journal |
| issn | 2306-5354 |
| language | English |
| last_indexed | 2024-03-11T03:57:03Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj.art-c25c477506b14461bf04bd8b64fdac672023-11-18T00:30:53ZengMDPI AGBioengineering2306-53542023-04-0110554010.3390/bioengineering10050540Intraluminal Thrombus Characteristics in AAA Patients: Non-Invasive Diagnosis Using CFDDjelloul Belkacemi0Miloud Tahar Abbes1Mohammad Al-Rawi2Ahmed M. Al-Jumaily3Sofiane Bachene4Boualem Laribi5Mechanics and Energetics Laboratory, Hassiba Ben Bouali University, Chlef 02000, AlgeriaMechanics and Energetics Laboratory, Hassiba Ben Bouali University, Chlef 02000, AlgeriaCenter for Engineering and Industrial Design, Waikato Institute of Technology, Hamilton 3240, New ZealandInstitute of Biomedical Technologies, Auckland University of Technology, Auckland 1010, New ZealandRadiologie, Centre d’Imagerie Médicale, Cheraga, Algiers 16000, AlgeriaFIMA Laboratory, Department of Technology, Djilali Bounaama University, Khemis Miliana 44225, AlgeriaAbdominal aortic aneurysms (AAA) continue to pose a high mortality risk despite advances in medical imaging and surgery. Intraluminal thrombus (ILT) is detected in most AAAs and may critically impact their development. Therefore, understanding ILT deposition and growth is of practical importance. To assist in managing these patients, the scientific community has been researching the relationship between intraluminal thrombus (ILT) and hemodynamic parameters wall shear stress (WSS) derivatives. This study analyzed three patient-specific AAA models reconstructed from CT scans using computational fluid dynamics (CFD) simulations and a pulsatile non-Newtonian blood flow model. The co-localization and relationship between WSS-based hemodynamic parameters and ILT deposition were examined. The results show that ILT tends to occur in regions of low velocity and time-averaged WSS (TAWSS) and high oscillation shear index (OSI), endothelial cell activation potential (ECAP), and relative residence time (RRT) values. ILT deposition areas were found in regions of low TAWSS and high OSI independently of the nature of flow near the wall characterized by transversal WSS (TransWSS). A new approach is suggested which is based on the estimation of CFD-based WSS indices specifically in the thinnest and thickest ILT areas of AAA patients; this approach is promising and supports the effectiveness of CFD as a decision-making tool for clinicians. Further research with a larger patient cohort and follow-up data are needed to confirm these findings.https://www.mdpi.com/2306-5354/10/5/540abdominal aortic aneurysmintraluminal thrombus thicknesscomputational fluid dynamicsnon-Newtonian modelwall shear stress based parameters |
| spellingShingle | Djelloul Belkacemi Miloud Tahar Abbes Mohammad Al-Rawi Ahmed M. Al-Jumaily Sofiane Bachene Boualem Laribi Intraluminal Thrombus Characteristics in AAA Patients: Non-Invasive Diagnosis Using CFD Bioengineering abdominal aortic aneurysm intraluminal thrombus thickness computational fluid dynamics non-Newtonian model wall shear stress based parameters |
| title | Intraluminal Thrombus Characteristics in AAA Patients: Non-Invasive Diagnosis Using CFD |
| title_full | Intraluminal Thrombus Characteristics in AAA Patients: Non-Invasive Diagnosis Using CFD |
| title_fullStr | Intraluminal Thrombus Characteristics in AAA Patients: Non-Invasive Diagnosis Using CFD |
| title_full_unstemmed | Intraluminal Thrombus Characteristics in AAA Patients: Non-Invasive Diagnosis Using CFD |
| title_short | Intraluminal Thrombus Characteristics in AAA Patients: Non-Invasive Diagnosis Using CFD |
| title_sort | intraluminal thrombus characteristics in aaa patients non invasive diagnosis using cfd |
| topic | abdominal aortic aneurysm intraluminal thrombus thickness computational fluid dynamics non-Newtonian model wall shear stress based parameters |
| url | https://www.mdpi.com/2306-5354/10/5/540 |
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