Quinpramine ameliorates rat experimental autoimmune neuritis and redistributes MHC class II molecules.

Quinpramine ameliorates rat experimental autoimmune neuritis and redistributes MHC class II molecules.

Activation of inflammatory cells is central to the pathogenesis of autoimmune demyelinating diseases of the peripheral nervous system. The novel chimeric compound quinpramine--generated from imipramine and quinacrine--redistributes cholesterol rich membrane domains to intracellular compartments. We...

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Bibliographic Details
Main Authors: Gerd Meyer zu Hörste, Anne K Mausberg, Johanna I Müller, Helmar C Lehmann, Stefan Löber, Peter Gmeiner, Hans-Peter Hartung, Olaf Stüve, Carsten Korth, Bernd C Kieseier
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21698177/?tool=EBI

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