A Novel Synbiotic Alleviates Autoimmune Hepatitis by Modulating the Gut Microbiota-Liver Axis and Inhibiting the Hepatic TLR4/NF-κB/NLRP3 Signaling Pathway

A Novel Synbiotic Alleviates Autoimmune Hepatitis by Modulating the Gut Microbiota-Liver Axis and Inhibiting the Hepatic TLR4/NF-κB/NLRP3 Signaling Pathway

ABSTRACT Autoimmune hepatitis (AIH) is a liver disease characterized by chronic liver inflammation. The intestinal barrier and microbiome play critical roles in AIH progression. AIH treatment remains challenging because first-line drugs have limited efficacy and many side effects. Thus, there is gro...

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Bibliographic Details
Main Authors: Yongbo Kang, Xiaoyu Kuang, Huan Yan, Peng Ren, Xiaodan Yang, Haixia Liu, Qingqing Liu, Hao Yang, Xing Kang, Xiaorong Shen, Mingwei Tong, Lin Li, Xiaohui Wang, Linzhi Guo, Jieqiong Ma, Fan Zhang, Weiping Fan
Format: Article
Language:English
Published: American Society for Microbiology 2023-04-01
Series:mSystems
Subjects:
novel synbiotic
autoimmune hepatitis
intestinal permeability
intestinal flora
pyroptosis
Online Access:https://journals.asm.org/doi/10.1128/msystems.01127-22

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