External Evaluation of Population Pharmacokinetic Models of Busulfan in Chinese Adult Hematopoietic Stem Cell Transplantation Recipients

External Evaluation of Population Pharmacokinetic Models of Busulfan in Chinese Adult Hematopoietic Stem Cell Transplantation Recipients

Objective: Busulfan (BU) is a bi-functional DNA-alkylating agent used in patients undergoing hematopoietic stem cell transplantation (HSCT). Over the last decades, several population pharmacokinetic (pop PK) models of BU have been established, but external evaluation has not been performed for almos...

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Bibliographic Details
Main Authors:	Huiping Huang, Qingxia Liu, Xiaohan Zhang, Helin Xie, Maobai Liu, Nupur Chaphekar, Xuemei Wu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-07-01
Series:	Frontiers in Pharmacology
Subjects:	busulfan population pharmacokinetic model external evaluation hematopoietic stem cell transplantation precision medicine
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2022.835037/full

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