MicroRNA-19a-PTEN Axis Is Involved in the Developmental Decline of Axon Regenerative Capacity in Retinal Ganglion Cells

MicroRNA-19a-PTEN Axis Is Involved in the Developmental Decline of Axon Regenerative Capacity in Retinal Ganglion Cells

Irreversible blindness from glaucoma and optic neuropathies is attributed to retinal ganglion cells (RGCs) losing the ability to regenerate axons. While several transcription factors and proteins have demonstrated enhancement of axon regeneration after optic nerve injury, mechanisms contributing to...

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Bibliographic Details
Main Authors: Heather K. Mak, Jasmine S.Y. Yung, Robert N. Weinreb, Shuk Han Ng, Xu Cao, Tracy Y.C. Ho, Tsz Kin Ng, Wai Kit Chu, Wing Ho Yung, Kwong Wai Choy, Chi Chiu Wang, Tin Lap Lee, Christopher Kai-shun Leung
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
retinal ganglion cells
microRNA-19
phosphatase and tensin homolog
PTEN
axon regenerative capacity
axon regeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253120301578

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