Highly‐metastatic colorectal cancer cell released miR‐181a‐5p‐rich extracellular vesicles promote liver metastasis by activating hepatic stellate cells and remodelling the tumour microenvironment

Highly‐metastatic colorectal cancer cell released miR‐181a‐5p‐rich extracellular vesicles promote liver metastasis by activating hepatic stellate cells and remodelling the tumour microenvironment

Abstract Liver metastasis of colorectal cancer (CRLM) is the most common cause of CRC‐related mortality, and is typically caused by interactions between CRC cells and the tumour microenvironment (TME) in the liver. However, the molecular mechanisms underlying the crosstalk between tumour‐derived ext...

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Bibliographic Details
Main Authors: Senlin Zhao, Yushuai Mi, Binbin Zheng, Ping Wei, Yanzi Gu, Zhengxiang Zhang, Ye Xu, Sanjun Cai, Xinxiang Li, Dawei Li
Format: Article
Language:English
Published: Wiley 2022-01-01
Series:Journal of Extracellular Vesicles
Subjects:
CCL20/CCR6/ERK1/2/Elk‐1/miR‐181a‐5p feedback loop
colorectal liver metastasis
extracellular vesicle
hepatic stellate cell
miR‐181a‐5p
tumour microenvironment
Online Access:https://doi.org/10.1002/jev2.12186

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