Diseases associated with leaky hemichannels.
Hemichannels (HCs) and gap junction channels (GJCs) formed by protein subunits called connexins (Cxs) are major pathways for intercellular communication. While HCs connect the intracellular compartment with the extracellular milieu, GJCs allow the interchange of molecules between cytoplasm of two co...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2015-07-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00267/full |
| _version_ | 1811261648966516736 |
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| author | Mauricio Antonio Retamal Edison Pablo Reyes Isaac E Garcia Bernardo ePinto Agustin Demetrio Martinez Carlos eGonzalez |
| author_facet | Mauricio Antonio Retamal Edison Pablo Reyes Isaac E Garcia Bernardo ePinto Agustin Demetrio Martinez Carlos eGonzalez |
| author_sort | Mauricio Antonio Retamal |
| collection | DOAJ |
| description | Hemichannels (HCs) and gap junction channels (GJCs) formed by protein subunits called connexins (Cxs) are major pathways for intercellular communication. While HCs connect the intracellular compartment with the extracellular milieu, GJCs allow the interchange of molecules between cytoplasm of two contacting cells. Under physiological conditions, HCs are mostly closed, but they can open under certain stimuli allowing the release of autocrine and paracrine molecules. Moreover, some pathological conditions, like ischemia or other inflammation conditions, significantly increase HCs activity. In addition, some mutations in Cx genes associated with human diseases, such as deafness or cataracts, lead to the formation of more active HCs or leaky HCs. In this article we will revise cellular and molecular mechanisms underlying the appearance of leaky HCs, and the consequences of their expression in different cellular systems and animal models, in seeking a common pattern or pathological mechanism of disease. |
| first_indexed | 2024-04-12T19:09:24Z |
| format | Article |
| id | doaj.art-c266667daa924933a1cc1c56b92c67a3 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-04-12T19:09:24Z |
| publishDate | 2015-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-c266667daa924933a1cc1c56b92c67a32022-12-22T03:19:57ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022015-07-01910.3389/fncel.2015.00267151004Diseases associated with leaky hemichannels.Mauricio Antonio Retamal0Edison Pablo Reyes1Isaac E Garcia2Bernardo ePinto3Agustin Demetrio Martinez4Carlos eGonzalez5Universidad del DesarrolloUniversidad del DesarrolloUniversidad de ValparaisoUniversidad de ValparaisoUniversidad de ValparaisoUniversidad de ValparaisoHemichannels (HCs) and gap junction channels (GJCs) formed by protein subunits called connexins (Cxs) are major pathways for intercellular communication. While HCs connect the intracellular compartment with the extracellular milieu, GJCs allow the interchange of molecules between cytoplasm of two contacting cells. Under physiological conditions, HCs are mostly closed, but they can open under certain stimuli allowing the release of autocrine and paracrine molecules. Moreover, some pathological conditions, like ischemia or other inflammation conditions, significantly increase HCs activity. In addition, some mutations in Cx genes associated with human diseases, such as deafness or cataracts, lead to the formation of more active HCs or leaky HCs. In this article we will revise cellular and molecular mechanisms underlying the appearance of leaky HCs, and the consequences of their expression in different cellular systems and animal models, in seeking a common pattern or pathological mechanism of disease.http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00267/fullCell DeathConnexinsmutationsHuman Diseasehemichannelsgap junction channels |
| spellingShingle | Mauricio Antonio Retamal Edison Pablo Reyes Isaac E Garcia Bernardo ePinto Agustin Demetrio Martinez Carlos eGonzalez Diseases associated with leaky hemichannels. Frontiers in Cellular Neuroscience Cell Death Connexins mutations Human Disease hemichannels gap junction channels |
| title | Diseases associated with leaky hemichannels. |
| title_full | Diseases associated with leaky hemichannels. |
| title_fullStr | Diseases associated with leaky hemichannels. |
| title_full_unstemmed | Diseases associated with leaky hemichannels. |
| title_short | Diseases associated with leaky hemichannels. |
| title_sort | diseases associated with leaky hemichannels |
| topic | Cell Death Connexins mutations Human Disease hemichannels gap junction channels |
| url | http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00267/full |
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