Anti-c-fms Antibody Prevents Osteoclast Formation and Bone Resorption in Co-Culture of Osteoblasts and Osteoclast Precursors In Vitro and in Ovariectomized Mice

Anti-c-fms Antibody Prevents Osteoclast Formation and Bone Resorption in Co-Culture of Osteoblasts and Osteoclast Precursors In Vitro and in Ovariectomized Mice

Osteoporosis morphology is characterized by bone resorption and decreases in micro-architecture parameters. Anti-osteoporosis therapy targets osteoclasts because bone resorption is a unique function of osteoclasts. Anti-c-fms antibodies against the receptor for macrophage colony-stimulating factor (...

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Bibliographic Details
Main Authors: Yasuhiko Nara, Hideki Kitaura, Saika Ogawa, Wei-Ren Shen, Jiawei Qi, Fumitoshi Ohori, Takahiro Noguchi, Aseel Marahleh, Adya Pramusita, Ria Kinjo, Itaru Mizoguchi
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
osteoclast
OVX
anti-c-fms antibody
M-CSF
Online Access:https://www.mdpi.com/1422-0067/21/17/6120

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