Recent advances of therapeutic targets based on the molecular signature in breast cancer: genetic mutations and implications for current treatment paradigms
Abstract Breast cancer is the most common malignancy in women all over the world. Genetic background of women contributes to her risk of having breast cancer. Certain inherited DNA mutations can dramatically increase the risk of developing certain cancers and are responsible for many of the cancers...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-04-01
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| Series: | Journal of Hematology & Oncology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13045-019-0725-6 |
| _version_ | 1818459563950604288 |
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| author | Zeinab Safarpour Lima Mostafa Ghadamzadeh Farzad Tahmasebi Arashloo Ghazaleh Amjad Mohammad Reza Ebadi Ladan Younesi |
| author_facet | Zeinab Safarpour Lima Mostafa Ghadamzadeh Farzad Tahmasebi Arashloo Ghazaleh Amjad Mohammad Reza Ebadi Ladan Younesi |
| author_sort | Zeinab Safarpour Lima |
| collection | DOAJ |
| description | Abstract Breast cancer is the most common malignancy in women all over the world. Genetic background of women contributes to her risk of having breast cancer. Certain inherited DNA mutations can dramatically increase the risk of developing certain cancers and are responsible for many of the cancers that run in some families. Regarding the widespread multigene panels, whole exome sequencing is capable of providing the evaluation of genetic function mutations for development novel strategy in clinical trials. Targeting the mutant proteins involved in breast cancer can be an effective therapeutic approach for developing novel drugs. This systematic review discusses gene mutations linked to breast cancer, focusing on signaling pathways that are being targeted with investigational therapeutic strategies, where clinical trials could be potentially initiated in the future are being highlighted. |
| first_indexed | 2024-12-14T23:16:21Z |
| format | Article |
| id | doaj.art-c26c4e5430b44fbc8959ba013392e80c |
| institution | Directory Open Access Journal |
| issn | 1756-8722 |
| language | English |
| last_indexed | 2024-12-14T23:16:21Z |
| publishDate | 2019-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Hematology & Oncology |
| spelling | doaj.art-c26c4e5430b44fbc8959ba013392e80c2022-12-21T22:44:04ZengBMCJournal of Hematology & Oncology1756-87222019-04-0112112510.1186/s13045-019-0725-6Recent advances of therapeutic targets based on the molecular signature in breast cancer: genetic mutations and implications for current treatment paradigmsZeinab Safarpour Lima0Mostafa Ghadamzadeh1Farzad Tahmasebi Arashloo2Ghazaleh Amjad3Mohammad Reza Ebadi4Ladan Younesi5Shahid Akbar Abadi Clinical Research Development Unit (ShCRDU), Iran University of Medical Sciences (IUMS)Departement of Radiology, Hasheminejad Kidney Centre (HKC), Iran University of Medical SciencesClinical Research Unit, Afzalipour Hospital, Kerman University of Medical SciencesShahid Akbar Abadi Clinical Research Development Unit (ShCRDU), Iran University of Medical Sciences (IUMS)Shohadaye Haft-e-tir Hospital, Iran University of Medical Sciences (IUMS)Shahid Akbar Abadi Clinical Research Development Unit (ShCRDU), Iran University of Medical Sciences (IUMS)Abstract Breast cancer is the most common malignancy in women all over the world. Genetic background of women contributes to her risk of having breast cancer. Certain inherited DNA mutations can dramatically increase the risk of developing certain cancers and are responsible for many of the cancers that run in some families. Regarding the widespread multigene panels, whole exome sequencing is capable of providing the evaluation of genetic function mutations for development novel strategy in clinical trials. Targeting the mutant proteins involved in breast cancer can be an effective therapeutic approach for developing novel drugs. This systematic review discusses gene mutations linked to breast cancer, focusing on signaling pathways that are being targeted with investigational therapeutic strategies, where clinical trials could be potentially initiated in the future are being highlighted.http://link.springer.com/article/10.1186/s13045-019-0725-6BreastNew drugChromosomeMolecular patternsMutations |
| spellingShingle | Zeinab Safarpour Lima Mostafa Ghadamzadeh Farzad Tahmasebi Arashloo Ghazaleh Amjad Mohammad Reza Ebadi Ladan Younesi Recent advances of therapeutic targets based on the molecular signature in breast cancer: genetic mutations and implications for current treatment paradigms Journal of Hematology & Oncology Breast New drug Chromosome Molecular patterns Mutations |
| title | Recent advances of therapeutic targets based on the molecular signature in breast cancer: genetic mutations and implications for current treatment paradigms |
| title_full | Recent advances of therapeutic targets based on the molecular signature in breast cancer: genetic mutations and implications for current treatment paradigms |
| title_fullStr | Recent advances of therapeutic targets based on the molecular signature in breast cancer: genetic mutations and implications for current treatment paradigms |
| title_full_unstemmed | Recent advances of therapeutic targets based on the molecular signature in breast cancer: genetic mutations and implications for current treatment paradigms |
| title_short | Recent advances of therapeutic targets based on the molecular signature in breast cancer: genetic mutations and implications for current treatment paradigms |
| title_sort | recent advances of therapeutic targets based on the molecular signature in breast cancer genetic mutations and implications for current treatment paradigms |
| topic | Breast New drug Chromosome Molecular patterns Mutations |
| url | http://link.springer.com/article/10.1186/s13045-019-0725-6 |
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