Neutrophilia with subclinical Cushing’s disease: A case report and literature review
The increase in the level of neutrophils following subclinical Cushing’s disease is an uncommon clinical phenomenon that is characterized by insignificant biochemical or clinical evidence of hypercortisolism. In this study, we reported a 37-year-old female patient who presented with palpitations and...
| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | English |
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De Gruyter
2023-01-01
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| Series: | Open Life Sciences |
| Subjects: | |
| Acceso en liña: | https://doi.org/10.1515/biol-2022-0540 |
| _version_ | 1827969142226944000 |
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| author | Zhang Yan Lin Xiaoxi Liu Fei Shou Songtao Jin Heng |
| author_facet | Zhang Yan Lin Xiaoxi Liu Fei Shou Songtao Jin Heng |
| author_sort | Zhang Yan |
| collection | DOAJ |
| description | The increase in the level of neutrophils following subclinical Cushing’s disease is an uncommon clinical phenomenon that is characterized by insignificant biochemical or clinical evidence of hypercortisolism. In this study, we reported a 37-year-old female patient who presented with palpitations and fatigue, and showed increased neutrophils that were unaffected by anti-infection therapy. The patient was suspected of having a urinary tract infection because of occasionally with urinary frequency, urgency, increased procalcitonin, leukocytosis, and an increased proportion of neutrophils. The ineffectiveness of anti-infection therapy ruled out the possibility of urinary tract infection. Further examination of the bone marrow excluded the possibility of blood disease. However, the levels of blood cortisol and adrenocorticotropic hormone (ACTH) increased, and a magnetic resonance imaging examination revealed lesions in the sphenoidal sinus and sella area of the sphenoidal bone, which confirmed the relationship between increased glucocorticoids and increased neutrophils. This was further confirmed by follow-up surgery and pathological examination, which revealed silent corticotropin adenomas, which are characterized by the lack of biochemical or clinical evidence of hypercortisolism with positive immunostaining for ACTH. |
| first_indexed | 2024-04-09T18:33:24Z |
| format | Article |
| id | doaj.art-c26e8307cfbb4a6dba91f3f9dfbbe7df |
| institution | Directory Open Access Journal |
| issn | 2391-5412 |
| language | English |
| last_indexed | 2024-04-09T18:33:24Z |
| publishDate | 2023-01-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Life Sciences |
| spelling | doaj.art-c26e8307cfbb4a6dba91f3f9dfbbe7df2023-04-11T17:07:12ZengDe GruyterOpen Life Sciences2391-54122023-01-01181310310.1515/biol-2022-0540Neutrophilia with subclinical Cushing’s disease: A case report and literature reviewZhang Yan0Lin Xiaoxi1Liu Fei2Shou Songtao3Jin Heng4Department of Emergency Medicine, Tianjin Medical University General Hospital, Tianjin 300052, P.R. ChinaDepartment of Emergency Medicine, Tianjin Medical University General Hospital, Tianjin 300052, P.R. ChinaDepartment of Emergency Medicine, Tianjin Medical University General Hospital, Tianjin 300052, P.R. ChinaDepartment of Emergency Medicine, Tianjin Medical University General Hospital, Tianjin 300052, P.R. ChinaDepartment of Emergency Medicine, Tianjin Medical University General Hospital, Tianjin 300052, P.R. ChinaThe increase in the level of neutrophils following subclinical Cushing’s disease is an uncommon clinical phenomenon that is characterized by insignificant biochemical or clinical evidence of hypercortisolism. In this study, we reported a 37-year-old female patient who presented with palpitations and fatigue, and showed increased neutrophils that were unaffected by anti-infection therapy. The patient was suspected of having a urinary tract infection because of occasionally with urinary frequency, urgency, increased procalcitonin, leukocytosis, and an increased proportion of neutrophils. The ineffectiveness of anti-infection therapy ruled out the possibility of urinary tract infection. Further examination of the bone marrow excluded the possibility of blood disease. However, the levels of blood cortisol and adrenocorticotropic hormone (ACTH) increased, and a magnetic resonance imaging examination revealed lesions in the sphenoidal sinus and sella area of the sphenoidal bone, which confirmed the relationship between increased glucocorticoids and increased neutrophils. This was further confirmed by follow-up surgery and pathological examination, which revealed silent corticotropin adenomas, which are characterized by the lack of biochemical or clinical evidence of hypercortisolism with positive immunostaining for ACTH.https://doi.org/10.1515/biol-2022-0540subclinical cushing's diseasesilent corticotropin adenomasleukocytosispituitary adenomacase report |
| spellingShingle | Zhang Yan Lin Xiaoxi Liu Fei Shou Songtao Jin Heng Neutrophilia with subclinical Cushing’s disease: A case report and literature review Open Life Sciences subclinical cushing's disease silent corticotropin adenomas leukocytosis pituitary adenoma case report |
| title | Neutrophilia with subclinical Cushing’s disease: A case report and literature review |
| title_full | Neutrophilia with subclinical Cushing’s disease: A case report and literature review |
| title_fullStr | Neutrophilia with subclinical Cushing’s disease: A case report and literature review |
| title_full_unstemmed | Neutrophilia with subclinical Cushing’s disease: A case report and literature review |
| title_short | Neutrophilia with subclinical Cushing’s disease: A case report and literature review |
| title_sort | neutrophilia with subclinical cushing s disease a case report and literature review |
| topic | subclinical cushing's disease silent corticotropin adenomas leukocytosis pituitary adenoma case report |
| url | https://doi.org/10.1515/biol-2022-0540 |
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