Serum immunoglobulin levels in patients with lymphoproliferative diseases in Erbil, Kurdistan region, Iraq
Background and objectives: Lymphoproliferative neoplasms are among the commonest human neoplasia. Immune dysregulation is frequently associated with many of these diseases, particularly those related to B-cell origin. This study aimed to find out the immunological status of newly diagnosed patients...
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| Format: | Article |
| Language: | English |
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Hawler Medical University
2017-12-01
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| Series: | Zanco Journal of Medical Sciences |
| Subjects: | |
| Online Access: | http://zjms-hmu.org/files/articles/281217030656.pdf |
| _version_ | 1818827362707439616 |
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| author | Karwan Bahram Maulood Abdulkadir Aziz Alnaqshabandi |
| author_facet | Karwan Bahram Maulood Abdulkadir Aziz Alnaqshabandi |
| author_sort | Karwan Bahram Maulood |
| collection | DOAJ |
| description | Background and objectives: Lymphoproliferative neoplasms are among the commonest human neoplasia. Immune dysregulation is frequently associated with many of these diseases, particularly those related to B-cell origin. This study aimed to find out the immunological status of newly diagnosed patients with lymphoproliferative disorders.
Methods: This study was carried out in Erbil province during the period from November 2010 to April 2011. Fifty two newly diagnosed patients (34 males and 18 females) with lymphoproliferative disorders referred to Nnakaly Hospital for blood disease and 20 healthy control subjects had been included in this study. Determination of immunoglobulin subclasses by radial immunodiffusion in addition serum protein electrophoresis has been performed for each sample for the detection of monoclonal bands.
Results: Serum IgM and IgA level were decreased in all groups of patients with different lymphoproliferative disorders compared to control group. Serum IgG level showed insignificant reduction in acute lymphocytic leukemia and chronic lymphocytic leukemia patients, but it was increased in non Hodgkin lymphoma, Hodgkin lymphoma and multiple myeloma patients. Paraproteinemia had been seen in all patients with multiple myeloma while only 10% of chronic lymphocytic leukemia and non Hodgkin lymphoma showed paraproteinemia. No M-band had been noticed in acute lymphocytic leukemia and Hodgkin lymphoma.
Conclusion: There were some conflicting data regarding serum immunoglobulin levels in newly diagnosed patients with lymphoproliferative disorders in Erbil, Iraq. |
| first_indexed | 2024-12-19T00:42:21Z |
| format | Article |
| id | doaj.art-c26f0e87115340fd8b66056c6d14589a |
| institution | Directory Open Access Journal |
| issn | 1995-5588 1995-5596 |
| language | English |
| last_indexed | 2024-12-19T00:42:21Z |
| publishDate | 2017-12-01 |
| publisher | Hawler Medical University |
| record_format | Article |
| series | Zanco Journal of Medical Sciences |
| spelling | doaj.art-c26f0e87115340fd8b66056c6d14589a2022-12-21T20:44:29ZengHawler Medical UniversityZanco Journal of Medical Sciences1995-55881995-55962017-12-012131930193710.15218/zjms.2017.053Serum immunoglobulin levels in patients with lymphoproliferative diseases in Erbil, Kurdistan region, IraqKarwan Bahram Maulood0Abdulkadir Aziz Alnaqshabandi1Erbil Directorate of HealthHawler Medical UniversityBackground and objectives: Lymphoproliferative neoplasms are among the commonest human neoplasia. Immune dysregulation is frequently associated with many of these diseases, particularly those related to B-cell origin. This study aimed to find out the immunological status of newly diagnosed patients with lymphoproliferative disorders. Methods: This study was carried out in Erbil province during the period from November 2010 to April 2011. Fifty two newly diagnosed patients (34 males and 18 females) with lymphoproliferative disorders referred to Nnakaly Hospital for blood disease and 20 healthy control subjects had been included in this study. Determination of immunoglobulin subclasses by radial immunodiffusion in addition serum protein electrophoresis has been performed for each sample for the detection of monoclonal bands. Results: Serum IgM and IgA level were decreased in all groups of patients with different lymphoproliferative disorders compared to control group. Serum IgG level showed insignificant reduction in acute lymphocytic leukemia and chronic lymphocytic leukemia patients, but it was increased in non Hodgkin lymphoma, Hodgkin lymphoma and multiple myeloma patients. Paraproteinemia had been seen in all patients with multiple myeloma while only 10% of chronic lymphocytic leukemia and non Hodgkin lymphoma showed paraproteinemia. No M-band had been noticed in acute lymphocytic leukemia and Hodgkin lymphoma. Conclusion: There were some conflicting data regarding serum immunoglobulin levels in newly diagnosed patients with lymphoproliferative disorders in Erbil, Iraq.http://zjms-hmu.org/files/articles/281217030656.pdfLymphoproliferative disordersImmunoglobulinParaprotein |
| spellingShingle | Karwan Bahram Maulood Abdulkadir Aziz Alnaqshabandi Serum immunoglobulin levels in patients with lymphoproliferative diseases in Erbil, Kurdistan region, Iraq Zanco Journal of Medical Sciences Lymphoproliferative disorders Immunoglobulin Paraprotein |
| title | Serum immunoglobulin levels in patients with lymphoproliferative diseases in Erbil, Kurdistan region, Iraq |
| title_full | Serum immunoglobulin levels in patients with lymphoproliferative diseases in Erbil, Kurdistan region, Iraq |
| title_fullStr | Serum immunoglobulin levels in patients with lymphoproliferative diseases in Erbil, Kurdistan region, Iraq |
| title_full_unstemmed | Serum immunoglobulin levels in patients with lymphoproliferative diseases in Erbil, Kurdistan region, Iraq |
| title_short | Serum immunoglobulin levels in patients with lymphoproliferative diseases in Erbil, Kurdistan region, Iraq |
| title_sort | serum immunoglobulin levels in patients with lymphoproliferative diseases in erbil kurdistan region iraq |
| topic | Lymphoproliferative disorders Immunoglobulin Paraprotein |
| url | http://zjms-hmu.org/files/articles/281217030656.pdf |
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