Markers of apoptosis in patients with type 1 diabetes mellitus at the onset of the disease
Aim. This work was to study activation markers of apoptosis (CD95, CD95L) on peripheral blood lymphocytes of patients with type 1 diabetes mellitus (DM1) at the onset of the disease. Materials and methods. A total of 33 patients (25 men and 8 women) divided into 2 groups were available for biochem...
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| Format: | Article |
| Language: | English |
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Endocrinology Research Centre
2009-12-01
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| Series: | Сахарный диабет |
| Subjects: | |
| Online Access: | https://www.dia-endojournals.ru/jour/article/view/5711 |
| _version_ | 1797255305010085888 |
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| author | Elena Vladimirovna Pekareva Tatiana Vasil'evna Nikonova Vera Anatol'evna Gorelysheva Yana Stanislavovna Zvereva Svetlana Mikhailovna Stepanova Sergey Alexandrovich Prokof'ev Olga Mikhailovna Smirnova |
| author_facet | Elena Vladimirovna Pekareva Tatiana Vasil'evna Nikonova Vera Anatol'evna Gorelysheva Yana Stanislavovna Zvereva Svetlana Mikhailovna Stepanova Sergey Alexandrovich Prokof'ev Olga Mikhailovna Smirnova |
| author_sort | Elena Vladimirovna Pekareva |
| collection | DOAJ |
| description | Aim. This work was to study activation markers of apoptosis (CD95, CD95L) on peripheral blood lymphocytes of patients with type 1 diabetes mellitus (DM1) at the onset of the disease. Materials and methods. A total of 33 patients (25 men and 8 women) divided into 2 groups were available for biochemical, genetic, and immunological examination. Results. Those with the ?classical? onset of DM1 had significantly fewer CD95-expressing lymphocytes and more CD95L+ lymphocytes than control subjects. Carriers of genes responsible for high risk of DM1 showed especially large number of lymphocytes expressing CD95L. Conclusion. It is conjectured that DM1 is characterized by the suppression of mechanism controlling apoptosis of activated lymphocytes that may promote prolongation of the immune response. |
| first_indexed | 2024-03-08T15:22:41Z |
| format | Article |
| id | doaj.art-c2715a984cfc45a0a704c028f45ac9aa |
| institution | Directory Open Access Journal |
| issn | 2072-0351 2072-0378 |
| language | English |
| last_indexed | 2024-04-24T22:03:44Z |
| publishDate | 2009-12-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj.art-c2715a984cfc45a0a704c028f45ac9aa2024-03-20T11:47:55ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782009-12-01124738910.14341/2072-0351-57115669Markers of apoptosis in patients with type 1 diabetes mellitus at the onset of the diseaseElena Vladimirovna Pekareva0Tatiana Vasil'evna Nikonova1Vera Anatol'evna Gorelysheva2Yana Stanislavovna Zvereva3Svetlana Mikhailovna Stepanova4Sergey Alexandrovich Prokof'ev5Olga Mikhailovna Smirnova6Endocrinology Research Centre, MoscowEndocrinology Research Centre, MoscowEndocrinology Research Centre, MoscowEndocrinology Research Centre, MoscowEndocrinology Research Centre, MoscowEndocrinology Research Centre, MoscowEndocrinology Research Centre, MoscowAim. This work was to study activation markers of apoptosis (CD95, CD95L) on peripheral blood lymphocytes of patients with type 1 diabetes mellitus (DM1) at the onset of the disease. Materials and methods. A total of 33 patients (25 men and 8 women) divided into 2 groups were available for biochemical, genetic, and immunological examination. Results. Those with the ?classical? onset of DM1 had significantly fewer CD95-expressing lymphocytes and more CD95L+ lymphocytes than control subjects. Carriers of genes responsible for high risk of DM1 showed especially large number of lymphocytes expressing CD95L. Conclusion. It is conjectured that DM1 is characterized by the suppression of mechanism controlling apoptosis of activated lymphocytes that may promote prolongation of the immune response.https://www.dia-endojournals.ru/jour/article/view/5711type 1 diabetes mellitusapoptosiscd95cd95lcd95cd95l |
| spellingShingle | Elena Vladimirovna Pekareva Tatiana Vasil'evna Nikonova Vera Anatol'evna Gorelysheva Yana Stanislavovna Zvereva Svetlana Mikhailovna Stepanova Sergey Alexandrovich Prokof'ev Olga Mikhailovna Smirnova Markers of apoptosis in patients with type 1 diabetes mellitus at the onset of the disease Сахарный диабет type 1 diabetes mellitus apoptosis cd95 cd95l cd95 cd95l |
| title | Markers of apoptosis in patients with type 1 diabetes mellitus at the onset of the disease |
| title_full | Markers of apoptosis in patients with type 1 diabetes mellitus at the onset of the disease |
| title_fullStr | Markers of apoptosis in patients with type 1 diabetes mellitus at the onset of the disease |
| title_full_unstemmed | Markers of apoptosis in patients with type 1 diabetes mellitus at the onset of the disease |
| title_short | Markers of apoptosis in patients with type 1 diabetes mellitus at the onset of the disease |
| title_sort | markers of apoptosis in patients with type 1 diabetes mellitus at the onset of the disease |
| topic | type 1 diabetes mellitus apoptosis cd95 cd95l cd95 cd95l |
| url | https://www.dia-endojournals.ru/jour/article/view/5711 |
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