Sex differences in coronary microvascular resistance measured by a computational fluid dynamics model
BackgroundIncreased coronary microvascular resistance (CMVR) is associated with coronary microvascular dysfunction (CMD). Although CMD is more common in women, sex-specific differences in CMVR have not been demonstrated previously.AimTo compare CMVR between men and women being investigated for chest...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1159160/full |
| _version_ | 1797786034515214336 |
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| author | Daniel J. Taylor Louise Aubiniere-Robb Rebecca Gosling Rebecca Gosling Rebecca Gosling Tom Newman Tom Newman D. Rodney Hose D. Rodney Hose Ian Halliday Ian Halliday Patricia V. Lawford Patricia V. Lawford Andrew J. Narracott Andrew J. Narracott Julian P. Gunn Julian P. Gunn Julian P. Gunn Paul D. Morris Paul D. Morris Paul D. Morris |
| author_facet | Daniel J. Taylor Louise Aubiniere-Robb Rebecca Gosling Rebecca Gosling Rebecca Gosling Tom Newman Tom Newman D. Rodney Hose D. Rodney Hose Ian Halliday Ian Halliday Patricia V. Lawford Patricia V. Lawford Andrew J. Narracott Andrew J. Narracott Julian P. Gunn Julian P. Gunn Julian P. Gunn Paul D. Morris Paul D. Morris Paul D. Morris |
| author_sort | Daniel J. Taylor |
| collection | DOAJ |
| description | BackgroundIncreased coronary microvascular resistance (CMVR) is associated with coronary microvascular dysfunction (CMD). Although CMD is more common in women, sex-specific differences in CMVR have not been demonstrated previously.AimTo compare CMVR between men and women being investigated for chest pain.Methods and resultsWe used a computational fluid dynamics (CFD) model of human coronary physiology to calculate absolute CMVR based on invasive coronary angiographic images and pressures in 203 coronary arteries from 144 individual patients. CMVR was significantly higher in women than men (860 [650–1,205] vs. 680 [520–865] WU, Z = −2.24, p = 0.025). None of the other major subgroup comparisons yielded any differences in CMVR.ConclusionCMVR was significantly higher in women compared with men. These sex-specific differences may help to explain the increased prevalence of CMD in women. |
| first_indexed | 2024-03-13T01:02:23Z |
| format | Article |
| id | doaj.art-c271b04563154ee089f6c6a8942328ac |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-03-13T01:02:23Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-c271b04563154ee089f6c6a8942328ac2023-07-06T11:21:57ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2023-07-011010.3389/fcvm.2023.11591601159160Sex differences in coronary microvascular resistance measured by a computational fluid dynamics modelDaniel J. Taylor0Louise Aubiniere-Robb1Rebecca Gosling2Rebecca Gosling3Rebecca Gosling4Tom Newman5Tom Newman6D. Rodney Hose7D. Rodney Hose8Ian Halliday9Ian Halliday10Patricia V. Lawford11Patricia V. Lawford12Andrew J. Narracott13Andrew J. Narracott14Julian P. Gunn15Julian P. Gunn16Julian P. Gunn17Paul D. Morris18Paul D. Morris19Paul D. Morris20Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United KingdomDepartment of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United KingdomDepartment of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United KingdomDepartment of Cardiology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United KingdomInsigneo Institute for in Silico Medicine, University of Sheffield, Sheffield, United KingdomDepartment of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United KingdomDepartment of Cardiology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United KingdomDepartment of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United KingdomInsigneo Institute for in Silico Medicine, University of Sheffield, Sheffield, United KingdomDepartment of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United KingdomInsigneo Institute for in Silico Medicine, University of Sheffield, Sheffield, United KingdomDepartment of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United KingdomInsigneo Institute for in Silico Medicine, University of Sheffield, Sheffield, United KingdomDepartment of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United KingdomInsigneo Institute for in Silico Medicine, University of Sheffield, Sheffield, United KingdomDepartment of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United KingdomDepartment of Cardiology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United KingdomInsigneo Institute for in Silico Medicine, University of Sheffield, Sheffield, United KingdomDepartment of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United KingdomDepartment of Cardiology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United KingdomInsigneo Institute for in Silico Medicine, University of Sheffield, Sheffield, United KingdomBackgroundIncreased coronary microvascular resistance (CMVR) is associated with coronary microvascular dysfunction (CMD). Although CMD is more common in women, sex-specific differences in CMVR have not been demonstrated previously.AimTo compare CMVR between men and women being investigated for chest pain.Methods and resultsWe used a computational fluid dynamics (CFD) model of human coronary physiology to calculate absolute CMVR based on invasive coronary angiographic images and pressures in 203 coronary arteries from 144 individual patients. CMVR was significantly higher in women than men (860 [650–1,205] vs. 680 [520–865] WU, Z = −2.24, p = 0.025). None of the other major subgroup comparisons yielded any differences in CMVR.ConclusionCMVR was significantly higher in women compared with men. These sex-specific differences may help to explain the increased prevalence of CMD in women.https://www.frontiersin.org/articles/10.3389/fcvm.2023.1159160/fullcoronary microvascular resistancesexcomputational fluid dynamicscoronary microvascular dysfunctioncoronary physiology |
| spellingShingle | Daniel J. Taylor Louise Aubiniere-Robb Rebecca Gosling Rebecca Gosling Rebecca Gosling Tom Newman Tom Newman D. Rodney Hose D. Rodney Hose Ian Halliday Ian Halliday Patricia V. Lawford Patricia V. Lawford Andrew J. Narracott Andrew J. Narracott Julian P. Gunn Julian P. Gunn Julian P. Gunn Paul D. Morris Paul D. Morris Paul D. Morris Sex differences in coronary microvascular resistance measured by a computational fluid dynamics model Frontiers in Cardiovascular Medicine coronary microvascular resistance sex computational fluid dynamics coronary microvascular dysfunction coronary physiology |
| title | Sex differences in coronary microvascular resistance measured by a computational fluid dynamics model |
| title_full | Sex differences in coronary microvascular resistance measured by a computational fluid dynamics model |
| title_fullStr | Sex differences in coronary microvascular resistance measured by a computational fluid dynamics model |
| title_full_unstemmed | Sex differences in coronary microvascular resistance measured by a computational fluid dynamics model |
| title_short | Sex differences in coronary microvascular resistance measured by a computational fluid dynamics model |
| title_sort | sex differences in coronary microvascular resistance measured by a computational fluid dynamics model |
| topic | coronary microvascular resistance sex computational fluid dynamics coronary microvascular dysfunction coronary physiology |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1159160/full |
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