mTOR Signaling in Metabolism and Cancer
The mechanistic/mammalian target of rapamycin (mTOR), a serine/threonine kinase, is a central regulator for human physiological activity. Deregulated mTOR signaling is implicated in a variety of disorders, such as cancer, obesity, diabetes, and neurodegenerative diseases. The papers published in thi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/10/2278 |
| _version_ | 1797551241497149440 |
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| author | Shile Huang |
| author_facet | Shile Huang |
| author_sort | Shile Huang |
| collection | DOAJ |
| description | The mechanistic/mammalian target of rapamycin (mTOR), a serine/threonine kinase, is a central regulator for human physiological activity. Deregulated mTOR signaling is implicated in a variety of disorders, such as cancer, obesity, diabetes, and neurodegenerative diseases. The papers published in this special issue summarize the current understanding of the mTOR pathway and its role in the regulation of tissue regeneration, regulatory T cell differentiation and function, and different types of cancer including hematologic malignancies, skin, prostate, breast, and head and neck cancer. The findings highlight that targeting the mTOR pathway is a promising strategy to fight against certain human diseases. |
| first_indexed | 2024-03-10T15:41:46Z |
| format | Article |
| id | doaj.art-c2729d4f60164f8a98c6f76de5fc0652 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T15:41:46Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-c2729d4f60164f8a98c6f76de5fc06522023-11-20T16:48:45ZengMDPI AGCells2073-44092020-10-01910227810.3390/cells9102278mTOR Signaling in Metabolism and CancerShile Huang0Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130-3932, USAThe mechanistic/mammalian target of rapamycin (mTOR), a serine/threonine kinase, is a central regulator for human physiological activity. Deregulated mTOR signaling is implicated in a variety of disorders, such as cancer, obesity, diabetes, and neurodegenerative diseases. The papers published in this special issue summarize the current understanding of the mTOR pathway and its role in the regulation of tissue regeneration, regulatory T cell differentiation and function, and different types of cancer including hematologic malignancies, skin, prostate, breast, and head and neck cancer. The findings highlight that targeting the mTOR pathway is a promising strategy to fight against certain human diseases.https://www.mdpi.com/2073-4409/9/10/2278mTORPI3KAkttissue regenerationregulatory T cellstumor |
| spellingShingle | Shile Huang mTOR Signaling in Metabolism and Cancer Cells mTOR PI3K Akt tissue regeneration regulatory T cells tumor |
| title | mTOR Signaling in Metabolism and Cancer |
| title_full | mTOR Signaling in Metabolism and Cancer |
| title_fullStr | mTOR Signaling in Metabolism and Cancer |
| title_full_unstemmed | mTOR Signaling in Metabolism and Cancer |
| title_short | mTOR Signaling in Metabolism and Cancer |
| title_sort | mtor signaling in metabolism and cancer |
| topic | mTOR PI3K Akt tissue regeneration regulatory T cells tumor |
| url | https://www.mdpi.com/2073-4409/9/10/2278 |
| work_keys_str_mv | AT shilehuang mtorsignalinginmetabolismandcancer |