Prophylactic administration of an extract from Plantaginis Semen and its major component aucubin inhibits mechanical allodynia caused by paclitaxel in mice

Prophylactic administration of an extract from Plantaginis Semen and its major component aucubin inhibits mechanical allodynia caused by paclitaxel in mice

The chemotherapeutic agent paclitaxel (PTX) causes peripheral neuropathy as a major dose-limiting side effect, and this peripheral neuropathy is difficult to control. Our previous report showed that prophylactic repetitive administration of goshajinkigan (牛車腎氣丸 niú chē shèn qì wán), but not hachimij...

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Bibliographic Details
Main Authors: Tsugunobu Andoh, Mitsuru Kato, Ryo Kitamura, Shizuka Mizoguchi, Daisuke Uta, Kazufumi Toume, Katsuko Komatsu, Yasushi Kuraishi
Format: Article
Language:English
Published: Elsevier 2016-07-01
Series:Journal of Traditional and Complementary Medicine
Subjects:
Paclitaxel
Aucubin
Plantaginis Semen
Allodynia
Online Access:http://www.sciencedirect.com/science/article/pii/S2225411015001170

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