The era of cryptic exons: implications for ALS-FTD
Abstract TDP-43 is an RNA-binding protein with a crucial nuclear role in splicing, and mislocalises from the nucleus to the cytoplasm in a range of neurodegenerative disorders. TDP-43 proteinopathy spans a spectrum of incurable, heterogeneous, and increasingly prevalent neurodegenerative diseases, i...
Main Authors: | Puja R. Mehta, Anna-Leigh Brown, Michael E. Ward, Pietro Fratta |
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Format: | Article |
Language: | English |
Published: |
BMC
2023-03-01
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Series: | Molecular Neurodegeneration |
Subjects: | |
Online Access: | https://doi.org/10.1186/s13024-023-00608-5 |
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