Current and New Novel Combination Treatments for Metastatic Triple-Negative Breast Cancer
Triple-negative breast cancer (TNBC) has a worse prognosis and remains the most challenging breast cancer subtype to treat. This is largely related to the heterogeneity of this disease and the lack of reliable oncological targets. In this review, we discuss the current standard-of-care treatment opt...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-07-01
|
| Series: | Current Oncology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1718-7729/29/7/377 |
| _version_ | 1797433693363503104 |
|---|---|
| author | Mehrnoosh Pauls Stephen Chia Nathalie LeVasseur |
| author_facet | Mehrnoosh Pauls Stephen Chia Nathalie LeVasseur |
| author_sort | Mehrnoosh Pauls |
| collection | DOAJ |
| description | Triple-negative breast cancer (TNBC) has a worse prognosis and remains the most challenging breast cancer subtype to treat. This is largely related to the heterogeneity of this disease and the lack of reliable oncological targets. In this review, we discuss the current standard-of-care treatment options for metastatic TNBC, including recent advances with the use of immunotherapy, PARP inhibitors and antibody-drug conjugates. This review also explores new agents and novel combinations arising in the field for the treatment of advanced TNBC. |
| first_indexed | 2024-03-09T10:20:37Z |
| format | Article |
| id | doaj.art-c2771e0882234a8db6deadabc902dee0 |
| institution | Directory Open Access Journal |
| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-09T10:20:37Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-c2771e0882234a8db6deadabc902dee02023-12-01T22:02:51ZengMDPI AGCurrent Oncology1198-00521718-77292022-07-012974748476710.3390/curroncol29070377Current and New Novel Combination Treatments for Metastatic Triple-Negative Breast CancerMehrnoosh Pauls0Stephen Chia1Nathalie LeVasseur2BC Cancer Vancouver Centre, University of British Columbia, 600 W 10th Ave, Vancouver, BC V5Z 4E6, CanadaBC Cancer Vancouver Centre, University of British Columbia, 600 W 10th Ave, Vancouver, BC V5Z 4E6, CanadaBC Cancer Vancouver Centre, University of British Columbia, 600 W 10th Ave, Vancouver, BC V5Z 4E6, CanadaTriple-negative breast cancer (TNBC) has a worse prognosis and remains the most challenging breast cancer subtype to treat. This is largely related to the heterogeneity of this disease and the lack of reliable oncological targets. In this review, we discuss the current standard-of-care treatment options for metastatic TNBC, including recent advances with the use of immunotherapy, PARP inhibitors and antibody-drug conjugates. This review also explores new agents and novel combinations arising in the field for the treatment of advanced TNBC.https://www.mdpi.com/1718-7729/29/7/377metastatic TNBCimmunotherapyPARP inhibitorantibody-drug conjugate (ADC)PI3K/AKT/mTOR |
| spellingShingle | Mehrnoosh Pauls Stephen Chia Nathalie LeVasseur Current and New Novel Combination Treatments for Metastatic Triple-Negative Breast Cancer Current Oncology metastatic TNBC immunotherapy PARP inhibitor antibody-drug conjugate (ADC) PI3K/AKT/mTOR |
| title | Current and New Novel Combination Treatments for Metastatic Triple-Negative Breast Cancer |
| title_full | Current and New Novel Combination Treatments for Metastatic Triple-Negative Breast Cancer |
| title_fullStr | Current and New Novel Combination Treatments for Metastatic Triple-Negative Breast Cancer |
| title_full_unstemmed | Current and New Novel Combination Treatments for Metastatic Triple-Negative Breast Cancer |
| title_short | Current and New Novel Combination Treatments for Metastatic Triple-Negative Breast Cancer |
| title_sort | current and new novel combination treatments for metastatic triple negative breast cancer |
| topic | metastatic TNBC immunotherapy PARP inhibitor antibody-drug conjugate (ADC) PI3K/AKT/mTOR |
| url | https://www.mdpi.com/1718-7729/29/7/377 |
| work_keys_str_mv | AT mehrnooshpauls currentandnewnovelcombinationtreatmentsformetastatictriplenegativebreastcancer AT stephenchia currentandnewnovelcombinationtreatmentsformetastatictriplenegativebreastcancer AT nathalielevasseur currentandnewnovelcombinationtreatmentsformetastatictriplenegativebreastcancer |