Atheroprotective Effects and Molecular Mechanism of Berberine
Cardiovascular diseases remain the leading cause of morbidity and mortality worldwide. Atherosclerosis is the main pathological basis of cardiovascular diseases and it is closely associated with hyperlipidemia, endothelial injury, macrophage-derived foam cells formation, proliferation and migration...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Molecular Biosciences |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2021.762673/full |
| _version_ | 1818427636720861184 |
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| author | Lu Xing Xin Zhou Ai-Hong Li Hui-Jin Li Chun-Xia He Wei Qin Dong Zhao Peng-Quan Li Li Zhu Hui-Ling Cao Hui-Ling Cao |
| author_facet | Lu Xing Xin Zhou Ai-Hong Li Hui-Jin Li Chun-Xia He Wei Qin Dong Zhao Peng-Quan Li Li Zhu Hui-Ling Cao Hui-Ling Cao |
| author_sort | Lu Xing |
| collection | DOAJ |
| description | Cardiovascular diseases remain the leading cause of morbidity and mortality worldwide. Atherosclerosis is the main pathological basis of cardiovascular diseases and it is closely associated with hyperlipidemia, endothelial injury, macrophage-derived foam cells formation, proliferation and migration of vascular smooth muscle cells (VSMCs), platelet aggregation, and altered gut microbiota. Various symptomatic treatments, that are currently used to inhibit atherosclerosis, need to be administered in long term and their adverse effects cannot be ignored. Berberine (BBR) has beneficial effects on atherosclerosis through regulating multiple aspects of its progression. This review highlights the recent advances in understanding the anti-atherosclerosis mechanism of BBR. BBR alleviated atherosclerosis by attenuation of dyslipidemia, correction of endothelial dysfunction, inhibition of macrophage inflammation and foam cell formation, activation of macrophage autophagy, regulation of the proliferation and migration of VSMCs, attenuation of platelet aggregation, and modulation of gut microbiota. This review would provide a modern scientific perspective to further understanding the molecular mechanism of BBR attenuating atherosclerosis and supply new ideas for atherosclerosis management. |
| first_indexed | 2024-12-14T14:48:53Z |
| format | Article |
| id | doaj.art-c2781799081c48a98d2f3d26c3088c29 |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-12-14T14:48:53Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-c2781799081c48a98d2f3d26c3088c292022-12-21T22:57:13ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2021-11-01810.3389/fmolb.2021.762673762673Atheroprotective Effects and Molecular Mechanism of BerberineLu Xing0Xin Zhou1Ai-Hong Li2Hui-Jin Li3Chun-Xia He4Wei Qin5Dong Zhao6Peng-Quan Li7Li Zhu8Hui-Ling Cao9Hui-Ling Cao10Shaanxi Key Laboratory of Ischemic Cardiovascular Disease, Institute of Basic and Translational Medicine, Xi’an Medical University, Xi’an, ChinaShaanxi Key Laboratory of Ischemic Cardiovascular Disease, Institute of Basic and Translational Medicine, Xi’an Medical University, Xi’an, ChinaShaanxi Key Laboratory of Chinese Herb and Natural Drug Development, Medicine Research Institute, Shaanxi Pharmaceutical Holding Group Co., Ltd., Xi’an, ChinaShaanxi Key Laboratory of Ischemic Cardiovascular Disease, Institute of Basic and Translational Medicine, Xi’an Medical University, Xi’an, ChinaShaanxi Key Laboratory of Ischemic Cardiovascular Disease, Institute of Basic and Translational Medicine, Xi’an Medical University, Xi’an, ChinaShaanxi Key Laboratory of Ischemic Cardiovascular Disease, Institute of Basic and Translational Medicine, Xi’an Medical University, Xi’an, ChinaShaanxi Key Laboratory of Ischemic Cardiovascular Disease, Institute of Basic and Translational Medicine, Xi’an Medical University, Xi’an, ChinaShaanxi Key Laboratory of Ischemic Cardiovascular Disease, Institute of Basic and Translational Medicine, Xi’an Medical University, Xi’an, ChinaShaanxi Key Laboratory of Ischemic Cardiovascular Disease, Institute of Basic and Translational Medicine, Xi’an Medical University, Xi’an, ChinaShaanxi Key Laboratory of Ischemic Cardiovascular Disease, Institute of Basic and Translational Medicine, Xi’an Medical University, Xi’an, ChinaShaanxi Key Laboratory of Chinese Herb and Natural Drug Development, Medicine Research Institute, Shaanxi Pharmaceutical Holding Group Co., Ltd., Xi’an, ChinaCardiovascular diseases remain the leading cause of morbidity and mortality worldwide. Atherosclerosis is the main pathological basis of cardiovascular diseases and it is closely associated with hyperlipidemia, endothelial injury, macrophage-derived foam cells formation, proliferation and migration of vascular smooth muscle cells (VSMCs), platelet aggregation, and altered gut microbiota. Various symptomatic treatments, that are currently used to inhibit atherosclerosis, need to be administered in long term and their adverse effects cannot be ignored. Berberine (BBR) has beneficial effects on atherosclerosis through regulating multiple aspects of its progression. This review highlights the recent advances in understanding the anti-atherosclerosis mechanism of BBR. BBR alleviated atherosclerosis by attenuation of dyslipidemia, correction of endothelial dysfunction, inhibition of macrophage inflammation and foam cell formation, activation of macrophage autophagy, regulation of the proliferation and migration of VSMCs, attenuation of platelet aggregation, and modulation of gut microbiota. This review would provide a modern scientific perspective to further understanding the molecular mechanism of BBR attenuating atherosclerosis and supply new ideas for atherosclerosis management.https://www.frontiersin.org/articles/10.3389/fmolb.2021.762673/fullatherosclerosisberberinemolecular mechanismcell targetsgut microbiota |
| spellingShingle | Lu Xing Xin Zhou Ai-Hong Li Hui-Jin Li Chun-Xia He Wei Qin Dong Zhao Peng-Quan Li Li Zhu Hui-Ling Cao Hui-Ling Cao Atheroprotective Effects and Molecular Mechanism of Berberine Frontiers in Molecular Biosciences atherosclerosis berberine molecular mechanism cell targets gut microbiota |
| title | Atheroprotective Effects and Molecular Mechanism of Berberine |
| title_full | Atheroprotective Effects and Molecular Mechanism of Berberine |
| title_fullStr | Atheroprotective Effects and Molecular Mechanism of Berberine |
| title_full_unstemmed | Atheroprotective Effects and Molecular Mechanism of Berberine |
| title_short | Atheroprotective Effects and Molecular Mechanism of Berberine |
| title_sort | atheroprotective effects and molecular mechanism of berberine |
| topic | atherosclerosis berberine molecular mechanism cell targets gut microbiota |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2021.762673/full |
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