Multi-Lineage Evolution in Viral Populations Driven by Host Immune Systems
Viruses evolve in the background of host immune systems that exert selective pressure and drive viral evolutionary trajectories. This interaction leads to different evolutionary patterns in antigenic space. Examples observed in nature include the effectively one-dimensional escape characteristic of...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019-07-01
|
| Series: | Pathogens |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-0817/8/3/115 |
| _version_ | 1798034400628178944 |
|---|---|
| author | Jacopo Marchi Michael Lässig Thierry Mora Aleksandra M. Walczak |
| author_facet | Jacopo Marchi Michael Lässig Thierry Mora Aleksandra M. Walczak |
| author_sort | Jacopo Marchi |
| collection | DOAJ |
| description | Viruses evolve in the background of host immune systems that exert selective pressure and drive viral evolutionary trajectories. This interaction leads to different evolutionary patterns in antigenic space. Examples observed in nature include the effectively one-dimensional escape characteristic of influenza A and the prolonged coexistence of lineages in influenza B. Here, we use an evolutionary model for viruses in the presence of immune host systems with finite memory to obtain a phase diagram of evolutionary patterns in a two-dimensional antigenic space. We find that, for small effective mutation rates and mutation jump ranges, a single lineage is the only stable solution. Large effective mutation rates combined with large mutational jumps in antigenic space lead to multiple stably co-existing lineages over prolonged evolutionary periods. These results combined with observations from data constrain the parameter regimes for the adaptation of viruses, including influenza. |
| first_indexed | 2024-04-11T20:43:50Z |
| format | Article |
| id | doaj.art-c27978befb3d444ba36bfa61596df20e |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-04-11T20:43:50Z |
| publishDate | 2019-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-c27978befb3d444ba36bfa61596df20e2022-12-22T04:04:07ZengMDPI AGPathogens2076-08172019-07-018311510.3390/pathogens8030115pathogens8030115Multi-Lineage Evolution in Viral Populations Driven by Host Immune SystemsJacopo Marchi0Michael Lässig1Thierry Mora2Aleksandra M. Walczak3Laboratoire de physique de l’École normale supérieure (PSL University), CNRS, Sorbonne Université, and Université de Paris, 75005 Paris, FranceInstitute of Theoretical Physics, University of Cologne, 50937 Cologne, GermanyLaboratoire de physique de l’École normale supérieure (PSL University), CNRS, Sorbonne Université, and Université de Paris, 75005 Paris, FranceLaboratoire de physique de l’École normale supérieure (PSL University), CNRS, Sorbonne Université, and Université de Paris, 75005 Paris, FranceViruses evolve in the background of host immune systems that exert selective pressure and drive viral evolutionary trajectories. This interaction leads to different evolutionary patterns in antigenic space. Examples observed in nature include the effectively one-dimensional escape characteristic of influenza A and the prolonged coexistence of lineages in influenza B. Here, we use an evolutionary model for viruses in the presence of immune host systems with finite memory to obtain a phase diagram of evolutionary patterns in a two-dimensional antigenic space. We find that, for small effective mutation rates and mutation jump ranges, a single lineage is the only stable solution. Large effective mutation rates combined with large mutational jumps in antigenic space lead to multiple stably co-existing lineages over prolonged evolutionary periods. These results combined with observations from data constrain the parameter regimes for the adaptation of viruses, including influenza.https://www.mdpi.com/2076-0817/8/3/115co-evolutionviral-immune dynamicsstochastic modeling |
| spellingShingle | Jacopo Marchi Michael Lässig Thierry Mora Aleksandra M. Walczak Multi-Lineage Evolution in Viral Populations Driven by Host Immune Systems Pathogens co-evolution viral-immune dynamics stochastic modeling |
| title | Multi-Lineage Evolution in Viral Populations Driven by Host Immune Systems |
| title_full | Multi-Lineage Evolution in Viral Populations Driven by Host Immune Systems |
| title_fullStr | Multi-Lineage Evolution in Viral Populations Driven by Host Immune Systems |
| title_full_unstemmed | Multi-Lineage Evolution in Viral Populations Driven by Host Immune Systems |
| title_short | Multi-Lineage Evolution in Viral Populations Driven by Host Immune Systems |
| title_sort | multi lineage evolution in viral populations driven by host immune systems |
| topic | co-evolution viral-immune dynamics stochastic modeling |
| url | https://www.mdpi.com/2076-0817/8/3/115 |
| work_keys_str_mv | AT jacopomarchi multilineageevolutioninviralpopulationsdrivenbyhostimmunesystems AT michaellassig multilineageevolutioninviralpopulationsdrivenbyhostimmunesystems AT thierrymora multilineageevolutioninviralpopulationsdrivenbyhostimmunesystems AT aleksandramwalczak multilineageevolutioninviralpopulationsdrivenbyhostimmunesystems |