TRAIL and IP-10 dynamics in pregnant women post COVID-19 vaccination: associations with neutralizing antibody potency
IntroductionThe aim of this study is to investigate changes in TNF-related apoptosis-inducing ligand (TRAIL) and gamma interferon-induced protein 10 (IP-10) after COVID-19 vaccination in pregnant women and to explore their association with neutralizing antibody (Nab) inhibition.MethodsThe study eval...
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2024.1358967/full |
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| author | Wei-Chun Chen Wei-Chun Chen Wei-Chun Chen Wei-Chun Chen Wei-Chun Chen Shu-Yu Hu Chao-Min Cheng Ching-Fen Shen Hui-Yu Chuang Chin-Ru Ker Chin-Ru Ker Der-Ji Sun Ching-Ju Shen |
| author_facet | Wei-Chun Chen Wei-Chun Chen Wei-Chun Chen Wei-Chun Chen Wei-Chun Chen Shu-Yu Hu Chao-Min Cheng Ching-Fen Shen Hui-Yu Chuang Chin-Ru Ker Chin-Ru Ker Der-Ji Sun Ching-Ju Shen |
| author_sort | Wei-Chun Chen |
| collection | DOAJ |
| description | IntroductionThe aim of this study is to investigate changes in TNF-related apoptosis-inducing ligand (TRAIL) and gamma interferon-induced protein 10 (IP-10) after COVID-19 vaccination in pregnant women and to explore their association with neutralizing antibody (Nab) inhibition.MethodsThe study evaluated 93 pregnant women who had previously received two (n=21), three (n=55) or four (n=17) doses of COVID-19 vaccine. Also we evaluated maternal blood samples that were collected during childbirth. The levels of TRAIL, IP-10 and Nab inhibition were measured using enzyme-linked immunosorbent assays (ELISA).Results and discussionOur study revealed four-dose group resulted in lower TRAIL levels when compared to the two-dose and three-dose groups (4.78 vs. 16.07 vs. 21.61 pg/ml, p = 0.014). The two-dose group had reduced IP-10 levels than the three-dose cohort (111.49 vs. 147.89 pg/ml, p=0.013), with no significant variation compared to the four-dose group. In addition, the four-dose group showed stronger Nab inhibition against specific strains (BA.2 and BA.5) than the three-dose group. A positive correlation was observed between TRAIL and IP-10 in the two-dose group, while this relationship was not found in other dose groups or between TRAIL/IP-10 and Nab inhibition. As the doses of the COVID-19 vaccine increase, the levels of TRAIL and IP-10 generally increase, only by the fourth dose, the group previously vaccinated with AZD1222 showed lower TRAIL but higher IP-10. Despite these changes, more doses of the vaccine consistently reinforced Nab inhibition, apparently without any relation to TRAIL and IP-10 levels. The variation may indicate the induction of immunological memory in vaccinated mothers, which justifies further research in the future. |
| first_indexed | 2024-04-24T22:22:49Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-04-24T22:22:49Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-c27a918ca3e54789bb59deb9d7ca14882024-03-20T05:15:29ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882024-03-011410.3389/fcimb.2024.13589671358967TRAIL and IP-10 dynamics in pregnant women post COVID-19 vaccination: associations with neutralizing antibody potencyWei-Chun Chen0Wei-Chun Chen1Wei-Chun Chen2Wei-Chun Chen3Wei-Chun Chen4Shu-Yu Hu5Chao-Min Cheng6Ching-Fen Shen7Hui-Yu Chuang8Chin-Ru Ker9Chin-Ru Ker10Der-Ji Sun11Ching-Ju Shen12Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu, TaiwanDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital at Linkou, College of Medicine, Chang Gung University, Taoyuan, TaiwanDepartment of Obstetrics and Gynecology, New Taipei City Municipal Tucheng Hospital, New Taipei City, TaiwanInternational Intercollegiate Ph.D. Program, National Tsing Hua University, Hsinchu, TaiwanSchool of Traditional Chinese Medicine, Chang Gung University, Taoyuan, TaiwanInstitute of Biomedical Engineering, National Tsing Hua University, Hsinchu, TaiwanInstitute of Biomedical Engineering, National Tsing Hua University, Hsinchu, TaiwanDepartment of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, TaiwanDepartment of Obstetrics and Gynecology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanDepartment of Obstetrics and Gynecology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanGraduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, TaiwanDepartment of Obstetrics and Gynecology, Pojen Hospital, Kaohsiung, TaiwanDepartment of Obstetrics and Gynecology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanIntroductionThe aim of this study is to investigate changes in TNF-related apoptosis-inducing ligand (TRAIL) and gamma interferon-induced protein 10 (IP-10) after COVID-19 vaccination in pregnant women and to explore their association with neutralizing antibody (Nab) inhibition.MethodsThe study evaluated 93 pregnant women who had previously received two (n=21), three (n=55) or four (n=17) doses of COVID-19 vaccine. Also we evaluated maternal blood samples that were collected during childbirth. The levels of TRAIL, IP-10 and Nab inhibition were measured using enzyme-linked immunosorbent assays (ELISA).Results and discussionOur study revealed four-dose group resulted in lower TRAIL levels when compared to the two-dose and three-dose groups (4.78 vs. 16.07 vs. 21.61 pg/ml, p = 0.014). The two-dose group had reduced IP-10 levels than the three-dose cohort (111.49 vs. 147.89 pg/ml, p=0.013), with no significant variation compared to the four-dose group. In addition, the four-dose group showed stronger Nab inhibition against specific strains (BA.2 and BA.5) than the three-dose group. A positive correlation was observed between TRAIL and IP-10 in the two-dose group, while this relationship was not found in other dose groups or between TRAIL/IP-10 and Nab inhibition. As the doses of the COVID-19 vaccine increase, the levels of TRAIL and IP-10 generally increase, only by the fourth dose, the group previously vaccinated with AZD1222 showed lower TRAIL but higher IP-10. Despite these changes, more doses of the vaccine consistently reinforced Nab inhibition, apparently without any relation to TRAIL and IP-10 levels. The variation may indicate the induction of immunological memory in vaccinated mothers, which justifies further research in the future.https://www.frontiersin.org/articles/10.3389/fcimb.2024.1358967/fullTNF-related apoptosis-inducing ligandTRAILinterferon gamma-induced protein 10IP-10COVID-19 vaccineneutralizing antibody |
| spellingShingle | Wei-Chun Chen Wei-Chun Chen Wei-Chun Chen Wei-Chun Chen Wei-Chun Chen Shu-Yu Hu Chao-Min Cheng Ching-Fen Shen Hui-Yu Chuang Chin-Ru Ker Chin-Ru Ker Der-Ji Sun Ching-Ju Shen TRAIL and IP-10 dynamics in pregnant women post COVID-19 vaccination: associations with neutralizing antibody potency Frontiers in Cellular and Infection Microbiology TNF-related apoptosis-inducing ligand TRAIL interferon gamma-induced protein 10 IP-10 COVID-19 vaccine neutralizing antibody |
| title | TRAIL and IP-10 dynamics in pregnant women post COVID-19 vaccination: associations with neutralizing antibody potency |
| title_full | TRAIL and IP-10 dynamics in pregnant women post COVID-19 vaccination: associations with neutralizing antibody potency |
| title_fullStr | TRAIL and IP-10 dynamics in pregnant women post COVID-19 vaccination: associations with neutralizing antibody potency |
| title_full_unstemmed | TRAIL and IP-10 dynamics in pregnant women post COVID-19 vaccination: associations with neutralizing antibody potency |
| title_short | TRAIL and IP-10 dynamics in pregnant women post COVID-19 vaccination: associations with neutralizing antibody potency |
| title_sort | trail and ip 10 dynamics in pregnant women post covid 19 vaccination associations with neutralizing antibody potency |
| topic | TNF-related apoptosis-inducing ligand TRAIL interferon gamma-induced protein 10 IP-10 COVID-19 vaccine neutralizing antibody |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2024.1358967/full |
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