Novel approach to pathophysiology of type 2 diabetes mellitus
In this paper, we present a model of interplay between protein, lipid and carbohydrate metabolic pathways with regard to the carbon chain transporting systems, as well as generation and consumption of energy. This model elucidates the role of protein metabolism in the impairment of glucose tolerance...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Endocrinology Research Centre
2013-12-01
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| Series: | Сахарный диабет |
| Subjects: | |
| Online Access: | https://www.dia-endojournals.ru/jour/article/view/6283 |
| _version_ | 1797255236842160128 |
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| author | Emil' Kopeevich Mukhamedzhanov Oleg Viktorovich Esyrev |
| author_facet | Emil' Kopeevich Mukhamedzhanov Oleg Viktorovich Esyrev |
| author_sort | Emil' Kopeevich Mukhamedzhanov |
| collection | DOAJ |
| description | In this paper, we present a model of interplay between protein, lipid and carbohydrate metabolic pathways with regard to the carbon chain transporting systems, as well as generation and consumption of energy. This model elucidates the role of protein metabolism in the impairment of glucose tolerance during the absorption period. We also discuss the effects on energy homeostasis exercised by cytokines via mTOR pathway (the key factor of insulin signalling) considering the phenomenon of insulin resistance. |
| first_indexed | 2024-03-08T15:21:42Z |
| format | Article |
| id | doaj.art-c27ad7942a704513b503d3618588a6ae |
| institution | Directory Open Access Journal |
| issn | 2072-0351 2072-0378 |
| language | English |
| last_indexed | 2024-04-24T22:02:39Z |
| publishDate | 2013-12-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj.art-c27ad7942a704513b503d3618588a6ae2024-03-20T11:47:59ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782013-12-01164495110.14341/DM2013449-516228Novel approach to pathophysiology of type 2 diabetes mellitusEmil' Kopeevich Mukhamedzhanov0Oleg Viktorovich Esyrev1Anti-infective Drugs Research Centre, AlmatyAnti-infective Drugs Research Centre, AlmatyIn this paper, we present a model of interplay between protein, lipid and carbohydrate metabolic pathways with regard to the carbon chain transporting systems, as well as generation and consumption of energy. This model elucidates the role of protein metabolism in the impairment of glucose tolerance during the absorption period. We also discuss the effects on energy homeostasis exercised by cytokines via mTOR pathway (the key factor of insulin signalling) considering the phenomenon of insulin resistance.https://www.dia-endojournals.ru/jour/article/view/6283type 2 diabetes mellituspathogenesisprotein metabolismcytokinesinsulin resistance |
| spellingShingle | Emil' Kopeevich Mukhamedzhanov Oleg Viktorovich Esyrev Novel approach to pathophysiology of type 2 diabetes mellitus Сахарный диабет type 2 diabetes mellitus pathogenesis protein metabolism cytokines insulin resistance |
| title | Novel approach to pathophysiology of type 2 diabetes mellitus |
| title_full | Novel approach to pathophysiology of type 2 diabetes mellitus |
| title_fullStr | Novel approach to pathophysiology of type 2 diabetes mellitus |
| title_full_unstemmed | Novel approach to pathophysiology of type 2 diabetes mellitus |
| title_short | Novel approach to pathophysiology of type 2 diabetes mellitus |
| title_sort | novel approach to pathophysiology of type 2 diabetes mellitus |
| topic | type 2 diabetes mellitus pathogenesis protein metabolism cytokines insulin resistance |
| url | https://www.dia-endojournals.ru/jour/article/view/6283 |
| work_keys_str_mv | AT emilkopeevichmukhamedzhanov novelapproachtopathophysiologyoftype2diabetesmellitus AT olegviktorovichesyrev novelapproachtopathophysiologyoftype2diabetesmellitus |