Zolpidem Use and the Risk of Injury: A Population-Based Follow-Up Study.
BACKGROUND:While an association between zolpidem use and fracture and road accident was previously proposed, this study aimed to further explore the frequency and risk of a wide spectrum of injuries in subjects prescribed with zolpidem in Taiwan. METHODS:We identified 77,036 subjects who received Zo...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3694900?pdf=render |
| _version_ | 1818505001394241536 |
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| author | Shiu-Dong Chung Ching-Chun Lin Li-Hsuan Wang Herng-Ching Lin Jiunn-Horng Kang |
| author_facet | Shiu-Dong Chung Ching-Chun Lin Li-Hsuan Wang Herng-Ching Lin Jiunn-Horng Kang |
| author_sort | Shiu-Dong Chung |
| collection | DOAJ |
| description | BACKGROUND:While an association between zolpidem use and fracture and road accident was previously proposed, this study aimed to further explore the frequency and risk of a wide spectrum of injuries in subjects prescribed with zolpidem in Taiwan. METHODS:We identified 77,036 subjects who received Zolpidem treatment between 2005 and 2007. We randomly selected 77,036 comparison subjects who were frequency-matched based-on their demographic profiles. We individually tracked each subject for a 90-day period to identify those who subsequently suffered an injury. Cox proportional hazards regressions were performed to calculate the hazard ratio of injury between the two groups. RESULTS:The incidence rate of injury during the 90-day follow-up period for the total subjects was 18.11 (95% CI = 17.69-18.54) per 100 person-years; this was 24.35 (95% CI = 23.66-25.05) and 11.86 (95% CI = 11.39-12.36) for the study and comparison cohort, respectively. After adjusting for demographic variables, the hazard ratio (HR) of injury during the 90-day follow-up period for study subjects was 1.83 (95% CI = 1.73-1.94) that of comparison subjects. Additionally, compared to comparison subjects, the adjusted HR of injury during the 90-day follow-up period for study subjects who were prescribed Zolpidem for >30 days was as high as 2.17 (95% CI = 2.05-2.32). The adjusted HR of injury to blood vessels for study subjects was particularly high when compared to comparison subjects (HR = 6.34; 95% CI = 1.37-29.38). CONCLUSIONS:We found that patients prescribed with Zolpidem were at a higher risk for a wide range of injuries. |
| first_indexed | 2024-12-10T21:44:51Z |
| format | Article |
| id | doaj.art-c27bfd80b272425bbd772b19b62abf31 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T21:44:51Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-c27bfd80b272425bbd772b19b62abf312022-12-22T01:32:23ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0186e6745910.1371/journal.pone.0067459Zolpidem Use and the Risk of Injury: A Population-Based Follow-Up Study.Shiu-Dong ChungChing-Chun LinLi-Hsuan WangHerng-Ching LinJiunn-Horng KangBACKGROUND:While an association between zolpidem use and fracture and road accident was previously proposed, this study aimed to further explore the frequency and risk of a wide spectrum of injuries in subjects prescribed with zolpidem in Taiwan. METHODS:We identified 77,036 subjects who received Zolpidem treatment between 2005 and 2007. We randomly selected 77,036 comparison subjects who were frequency-matched based-on their demographic profiles. We individually tracked each subject for a 90-day period to identify those who subsequently suffered an injury. Cox proportional hazards regressions were performed to calculate the hazard ratio of injury between the two groups. RESULTS:The incidence rate of injury during the 90-day follow-up period for the total subjects was 18.11 (95% CI = 17.69-18.54) per 100 person-years; this was 24.35 (95% CI = 23.66-25.05) and 11.86 (95% CI = 11.39-12.36) for the study and comparison cohort, respectively. After adjusting for demographic variables, the hazard ratio (HR) of injury during the 90-day follow-up period for study subjects was 1.83 (95% CI = 1.73-1.94) that of comparison subjects. Additionally, compared to comparison subjects, the adjusted HR of injury during the 90-day follow-up period for study subjects who were prescribed Zolpidem for >30 days was as high as 2.17 (95% CI = 2.05-2.32). The adjusted HR of injury to blood vessels for study subjects was particularly high when compared to comparison subjects (HR = 6.34; 95% CI = 1.37-29.38). CONCLUSIONS:We found that patients prescribed with Zolpidem were at a higher risk for a wide range of injuries.http://europepmc.org/articles/PMC3694900?pdf=render |
| spellingShingle | Shiu-Dong Chung Ching-Chun Lin Li-Hsuan Wang Herng-Ching Lin Jiunn-Horng Kang Zolpidem Use and the Risk of Injury: A Population-Based Follow-Up Study. PLoS ONE |
| title | Zolpidem Use and the Risk of Injury: A Population-Based Follow-Up Study. |
| title_full | Zolpidem Use and the Risk of Injury: A Population-Based Follow-Up Study. |
| title_fullStr | Zolpidem Use and the Risk of Injury: A Population-Based Follow-Up Study. |
| title_full_unstemmed | Zolpidem Use and the Risk of Injury: A Population-Based Follow-Up Study. |
| title_short | Zolpidem Use and the Risk of Injury: A Population-Based Follow-Up Study. |
| title_sort | zolpidem use and the risk of injury a population based follow up study |
| url | http://europepmc.org/articles/PMC3694900?pdf=render |
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