Beware of Early Relapse in Rectal Cancer Patients Treated With Preoperative Chemoradiotherapy
Purpose Recurrence patterns in rectal cancer patients treated with preoperative chemoradiotherapy (PCRT) are needed to evaluate for establishing tailored surveillance protocol. Methods This study included 2,215 patients with locally-advanced mid and low rectal cancer treated with radical resection b...
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| Format: | Article |
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Korean Society of Coloproctology
2020-12-01
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| Series: | Annals of Coloproctology |
| Subjects: | |
| Online Access: | http://coloproctol.org/upload/pdf/ac-2020-06-11.pdf |
| _version_ | 1831567596478005248 |
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| author | Seul Gi Oh In Ja Park Ji-hyun Seo Young Il Kim Seok-Byung Lim Chan Wook Kim Yong Sik Yoon Jong Lyul Lee Chang Sik Yu Jin Cheon Kim |
| author_facet | Seul Gi Oh In Ja Park Ji-hyun Seo Young Il Kim Seok-Byung Lim Chan Wook Kim Yong Sik Yoon Jong Lyul Lee Chang Sik Yu Jin Cheon Kim |
| author_sort | Seul Gi Oh |
| collection | DOAJ |
| description | Purpose Recurrence patterns in rectal cancer patients treated with preoperative chemoradiotherapy (PCRT) are needed to evaluate for establishing tailored surveillance protocol. Methods This study included 2,215 patients with locally-advanced mid and low rectal cancer treated with radical resection between January 2005 and December 2012. Recurrence was evaluated according to receipt of PCRT; PCRT group (n = 1,258) and no-PCRT group (n = 957). Early recurrence occurred within 1 year of surgery and late recurrence after 3 years. The median follow-up duration was 65.7 ± 29 months. Results The overall recurrence rate was similar between the PCRT and no-PCRT group (25.8% vs. 24.9%, P = 0.622). The most common initial recurrence site was the lungs in both groups (50.6% vs. 49.6%, P = 0.864), followed by the liver, which was more common in the no-PCRT group (22.5% vs. 33.6%, P = 0.004). Most of the recurrence occurred within 3 years after surgery in both groups (85.3% vs. 85.8%, P = 0.862). Early recurrence was more common in the PCRT group than in the no-PCRT group (43.1% vs. 32.4%, P = 0.020). Recurrence within the first 6 months after surgery was significantly higher in the PCRT group than in the no-PCRT group (18.8% vs. 7.6%, P = 0.003). Lung (n = 27, 44.3%) and liver (n = 22, 36.1%) were the frequent the first relapsed site within 6 months after surgery in PCRT group. Conclusion Early recurrence within the first 1 year after surgery was more common in patients treated with PCRT. This difference would be considered for surveillance protocols and need to be evaluated in further studies. |
| first_indexed | 2024-12-17T12:00:33Z |
| format | Article |
| id | doaj.art-c27c549c29654f7096298cd1699dae8a |
| institution | Directory Open Access Journal |
| issn | 2287-9714 2287-9722 |
| language | English |
| last_indexed | 2024-12-17T12:00:33Z |
| publishDate | 2020-12-01 |
| publisher | Korean Society of Coloproctology |
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| series | Annals of Coloproctology |
| spelling | doaj.art-c27c549c29654f7096298cd1699dae8a2022-12-21T21:49:52ZengKorean Society of ColoproctologyAnnals of Coloproctology2287-97142287-97222020-12-0136638238910.3393/ac.2020.06.111734Beware of Early Relapse in Rectal Cancer Patients Treated With Preoperative ChemoradiotherapySeul Gi Oh0In Ja Park1Ji-hyun Seo2Young Il Kim3Seok-Byung Lim4Chan Wook Kim5Yong Sik Yoon6Jong Lyul Lee7Chang Sik Yu8Jin Cheon Kim9 Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Department of Colon and Rectal Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Division of Colorectal Surgery, Department of Surgery, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea Department of Colon and Rectal Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Department of Colon and Rectal Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Department of Colon and Rectal Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Department of Colon and Rectal Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Department of Colon and Rectal Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Department of Colon and Rectal Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Department of Colon and Rectal Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, KoreaPurpose Recurrence patterns in rectal cancer patients treated with preoperative chemoradiotherapy (PCRT) are needed to evaluate for establishing tailored surveillance protocol. Methods This study included 2,215 patients with locally-advanced mid and low rectal cancer treated with radical resection between January 2005 and December 2012. Recurrence was evaluated according to receipt of PCRT; PCRT group (n = 1,258) and no-PCRT group (n = 957). Early recurrence occurred within 1 year of surgery and late recurrence after 3 years. The median follow-up duration was 65.7 ± 29 months. Results The overall recurrence rate was similar between the PCRT and no-PCRT group (25.8% vs. 24.9%, P = 0.622). The most common initial recurrence site was the lungs in both groups (50.6% vs. 49.6%, P = 0.864), followed by the liver, which was more common in the no-PCRT group (22.5% vs. 33.6%, P = 0.004). Most of the recurrence occurred within 3 years after surgery in both groups (85.3% vs. 85.8%, P = 0.862). Early recurrence was more common in the PCRT group than in the no-PCRT group (43.1% vs. 32.4%, P = 0.020). Recurrence within the first 6 months after surgery was significantly higher in the PCRT group than in the no-PCRT group (18.8% vs. 7.6%, P = 0.003). Lung (n = 27, 44.3%) and liver (n = 22, 36.1%) were the frequent the first relapsed site within 6 months after surgery in PCRT group. Conclusion Early recurrence within the first 1 year after surgery was more common in patients treated with PCRT. This difference would be considered for surveillance protocols and need to be evaluated in further studies.http://coloproctol.org/upload/pdf/ac-2020-06-11.pdfrectal neoplasmsearly recurrencepreoperative chemoradiotherapysurveillancerecurrence pattern |
| spellingShingle | Seul Gi Oh In Ja Park Ji-hyun Seo Young Il Kim Seok-Byung Lim Chan Wook Kim Yong Sik Yoon Jong Lyul Lee Chang Sik Yu Jin Cheon Kim Beware of Early Relapse in Rectal Cancer Patients Treated With Preoperative Chemoradiotherapy Annals of Coloproctology rectal neoplasms early recurrence preoperative chemoradiotherapy surveillance recurrence pattern |
| title | Beware of Early Relapse in Rectal Cancer Patients Treated With Preoperative Chemoradiotherapy |
| title_full | Beware of Early Relapse in Rectal Cancer Patients Treated With Preoperative Chemoradiotherapy |
| title_fullStr | Beware of Early Relapse in Rectal Cancer Patients Treated With Preoperative Chemoradiotherapy |
| title_full_unstemmed | Beware of Early Relapse in Rectal Cancer Patients Treated With Preoperative Chemoradiotherapy |
| title_short | Beware of Early Relapse in Rectal Cancer Patients Treated With Preoperative Chemoradiotherapy |
| title_sort | beware of early relapse in rectal cancer patients treated with preoperative chemoradiotherapy |
| topic | rectal neoplasms early recurrence preoperative chemoradiotherapy surveillance recurrence pattern |
| url | http://coloproctol.org/upload/pdf/ac-2020-06-11.pdf |
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