Ribosomal RACK1 Regulates the Dendritic Arborization by Repressing FMRP Activity

Ribosomal RACK1 Regulates the Dendritic Arborization by Repressing FMRP Activity

FMRP is an RNA-binding protein that represses the translation of specific mRNAs. In neurons, its depletion determines the exaggerated translation of mRNAs leading to dendritic and axonal aberrant development, two peculiar features of Fragile X syndrome patients. However, how FMRP binds to translatio...

Full description

Bibliographic Details
Main Authors: Nicla Romano, Bruna Di Giacomo, Veronica Nobile, Antonella Borreca, Daniela Willems, Francesca Tilesi, Elisabetta Catalani, Manasi Agrawal, Kristy Welshhans, Sara Ricciardi, Davide Cervia, Marcello Ceci
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
neuron differentiation
RACK1
FMRP
translation
ribosomes
neurons
Online Access:https://www.mdpi.com/1422-0067/23/19/11857

Internet

https://www.mdpi.com/1422-0067/23/19/11857

Similar Items