Invasive phenotype in triple negative breast cancer is inhibited by blocking SIN3A–PF1 interaction through KLF9 mediated repression of ITGA6 and ITGB1

Invasive phenotype in triple negative breast cancer is inhibited by blocking SIN3A–PF1 interaction through KLF9 mediated repression of ITGA6 and ITGB1

SIN3A, a scaffold protein has regulatory functions in tumor biology. Through its Paired amphipathic helix (PAH2) domain, SIN3A interacts with PHF12 (PF1), a protein with SIN3 interaction domain (SID) that forms a complex with MRG15 and KDM5A/B. These components are often overexpressed in cancer. In...

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Bibliographic Details
Main Authors: Rama Kadamb, Boris A Leibovitch, Eduardo F Farias, Nisha Dahiya, Hemant Suryawanshi, Nidhi Bansal, Samuel Waxman
Format: Article
Language:English
Published: Elsevier 2022-02-01
Series:Translational Oncology
Subjects:
SIN3A
PF1
SID
PAH2 domain
KLF9
ITGB1
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523321003119

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