Invasive phenotype in triple negative breast cancer is inhibited by blocking SIN3A–PF1 interaction through KLF9 mediated repression of ITGA6 and ITGB1
SIN3A, a scaffold protein has regulatory functions in tumor biology. Through its Paired amphipathic helix (PAH2) domain, SIN3A interacts with PHF12 (PF1), a protein with SIN3 interaction domain (SID) that forms a complex with MRG15 and KDM5A/B. These components are often overexpressed in cancer. In...
Main Authors: | Rama Kadamb, Boris A Leibovitch, Eduardo F Farias, Nisha Dahiya, Hemant Suryawanshi, Nidhi Bansal, Samuel Waxman |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2022-02-01
|
Series: | Translational Oncology |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1936523321003119 |
Similar Items
-
Expression and prognostic analyses of ITGA11, ITGB4 and ITGB8 in human non-small cell lung cancer
by: Pancheng Wu, et al.
Published: (2019-12-01) -
The Sin3A/MAD1 Complex, through Its PAH2 Domain, Acts as a Second Repressor of Retinoic Acid Receptor Beta Expression in Breast Cancer Cells
by: Nisha Rani Dahiya, et al.
Published: (2022-03-01) -
Comprehensive pan-carcinoma analysis of ITGB1 distortion and its potential clinical significance for cancer immunity
by: Yuchang Fei, et al.
Published: (2024-02-01) -
Role of <i>ITGB3</i>, <i>GP1B1</i>, and <i>ITGA2</i> gene polymorphisms in platelet dysfunction in patients with COVID-19-associated lung damage
by: M. V. Osikov, et al.
Published: (2024-01-01) -
ITGB1BP1, a Novel Transcriptional Target of CD44-Downstream Signaling Promoting Cancer Cell Invasion
by: Ahmad SMS, et al.
Published: (2023-05-01)