Yap1 safeguards mouse embryonic stem cells from excessive apoptosis during differentiation

Yap1 safeguards mouse embryonic stem cells from excessive apoptosis during differentiation

Approximately, 30% of embryonic stem cells (ESCs) die after exiting self-renewal, but regulators of this process are not well known. Yap1 is a Hippo pathway transcriptional effector that plays numerous roles in development and cancer. However, its functions in ESC differentiation remain poorly chara...

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Bibliographic Details
Main Authors: Lucy LeBlanc, Bum-Kyu Lee, Andy C Yu, Mijeong Kim, Aparna V Kambhampati, Shannon M Dupont, Davide Seruggia, Byoung U Ryu, Stuart H Orkin, Jonghwan Kim
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-12-01
Series:eLife
Subjects:
Yap1
apoptosis
embryonic stem cells
differentiation
Online Access:https://elifesciences.org/articles/40167

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