Allele-Specific DNA Methylation and Its Interplay with Repressive Histone Marks at Promoter-Mutant TERT Genes

Allele-Specific DNA Methylation and Its Interplay with Repressive Histone Marks at Promoter-Mutant TERT Genes

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A mutation in the promoter of the Telomerase Reverse Transcriptase (TERT) gene is the most frequent noncoding mutation in cancer. The mutation drives unusual monoallelic expression of TERT, allowing immortalization. Here, we find that DNA methylation of the TERT CpG island (CGI) is also allele-speci...

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Bibliographic Details
Main Authors: Josh Lewis Stern, Richard D. Paucek, Franklin W. Huang, Mahmoud Ghandi, Ronald Nwumeh, James C. Costello, Thomas R. Cech
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:Cell Reports
Subjects:
telomerase
TERT promoter
Polycomb repressive complex 2
PRC2
5-methylcytosine
allele-specific
monoallelic
CpG island
cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717317977

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http://www.sciencedirect.com/science/article/pii/S2211124717317977

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