Female Asthmatic Patients Have Higher Risk to Develop Gemifloxacin-Associated Skin Rash, Highlighting Unique Delayed Onset Characteristics
Gemifloxacin is a common oral antibiotic for lower respiratory tract infection worldwide. We noticed an uncommon delayed onset skin rash in patients who received Gemifloxacin. Therefore, we retrospectively reviewed all patients who received Gemifloxacin from 1 January 2011 to 31 May 2016 in a univer...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-08-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/8/3/134 |
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| author | Chiou-Mei Wu Po-Ju Wei Yu-Ting Shen Hsu-Liang Chang Ying-Ming Tsai Hung-Fang Pan Yong-Chieh Chang Yu-Ching Wei Chih-Jen Yang |
| author_facet | Chiou-Mei Wu Po-Ju Wei Yu-Ting Shen Hsu-Liang Chang Ying-Ming Tsai Hung-Fang Pan Yong-Chieh Chang Yu-Ching Wei Chih-Jen Yang |
| author_sort | Chiou-Mei Wu |
| collection | DOAJ |
| description | Gemifloxacin is a common oral antibiotic for lower respiratory tract infection worldwide. We noticed an uncommon delayed onset skin rash in patients who received Gemifloxacin. Therefore, we retrospectively reviewed all patients who received Gemifloxacin from 1 January 2011 to 31 May 2016 in a university-affiliated hospital in Taiwan. A total of 1358 patients were enrolled, of whom 36 (2.65%) had skin eruptions. The female patients had a significantly higher odds ratio (OR) 2.24 (95% confidence interval (CI) 1.11−4.53, <i>p</i> = 0.021) of having skin eruptions. A history of asthma was also a significant risk factor (OR 2.04, 95% CI = 1.01−4.14, <i>p</i> = 0.043). Female asthmatic patients had the highest risk of skin eruptions (10/129, 7.2%) with an adjusted OR up to 4.45 (95% CI = 1.81−10.93, <i>p</i> < 0.001) compared to male and non-asthmatic patients. Of note, up to 58.3% (21/36) of the patients experienced a skin rash after they had completed and stopped Gemifloxacin. The median onset time was on the second day (ranging one to five days) after completing treatment. We reported that female asthmatic patients have the highest risk of Gemifloxacin-associated skin eruptions in Asia and that they highlighted a unique delayed onset skin rash. |
| first_indexed | 2024-12-10T04:20:30Z |
| format | Article |
| id | doaj.art-c27f88b94be342a78f172a743b467de4 |
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| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-12-10T04:20:30Z |
| publishDate | 2019-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-c27f88b94be342a78f172a743b467de42022-12-22T02:02:26ZengMDPI AGAntibiotics2079-63822019-08-018313410.3390/antibiotics8030134antibiotics8030134Female Asthmatic Patients Have Higher Risk to Develop Gemifloxacin-Associated Skin Rash, Highlighting Unique Delayed Onset CharacteristicsChiou-Mei Wu0Po-Ju Wei1Yu-Ting Shen2Hsu-Liang Chang3Ying-Ming Tsai4Hung-Fang Pan5Yong-Chieh Chang6Yu-Ching Wei7Chih-Jen Yang8Department of pharmacy, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80145, TaiwanDepartment of Internal Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80145, TaiwanDepartment of pharmacy, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80145, TaiwanDepartment of Internal Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80145, TaiwanDepartment of Internal Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80145, TaiwanDepartment of pharmacy, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80145, TaiwanDepartment of pharmacy, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80145, TaiwanDepartment of pathology, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, TaiwanDepartment of Internal Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80145, TaiwanGemifloxacin is a common oral antibiotic for lower respiratory tract infection worldwide. We noticed an uncommon delayed onset skin rash in patients who received Gemifloxacin. Therefore, we retrospectively reviewed all patients who received Gemifloxacin from 1 January 2011 to 31 May 2016 in a university-affiliated hospital in Taiwan. A total of 1358 patients were enrolled, of whom 36 (2.65%) had skin eruptions. The female patients had a significantly higher odds ratio (OR) 2.24 (95% confidence interval (CI) 1.11−4.53, <i>p</i> = 0.021) of having skin eruptions. A history of asthma was also a significant risk factor (OR 2.04, 95% CI = 1.01−4.14, <i>p</i> = 0.043). Female asthmatic patients had the highest risk of skin eruptions (10/129, 7.2%) with an adjusted OR up to 4.45 (95% CI = 1.81−10.93, <i>p</i> < 0.001) compared to male and non-asthmatic patients. Of note, up to 58.3% (21/36) of the patients experienced a skin rash after they had completed and stopped Gemifloxacin. The median onset time was on the second day (ranging one to five days) after completing treatment. We reported that female asthmatic patients have the highest risk of Gemifloxacin-associated skin eruptions in Asia and that they highlighted a unique delayed onset skin rash.https://www.mdpi.com/2079-6382/8/3/134Gemifloxacinadverse drug reactionskin rashfluoroquinolones |
| spellingShingle | Chiou-Mei Wu Po-Ju Wei Yu-Ting Shen Hsu-Liang Chang Ying-Ming Tsai Hung-Fang Pan Yong-Chieh Chang Yu-Ching Wei Chih-Jen Yang Female Asthmatic Patients Have Higher Risk to Develop Gemifloxacin-Associated Skin Rash, Highlighting Unique Delayed Onset Characteristics Antibiotics Gemifloxacin adverse drug reaction skin rash fluoroquinolones |
| title | Female Asthmatic Patients Have Higher Risk to Develop Gemifloxacin-Associated Skin Rash, Highlighting Unique Delayed Onset Characteristics |
| title_full | Female Asthmatic Patients Have Higher Risk to Develop Gemifloxacin-Associated Skin Rash, Highlighting Unique Delayed Onset Characteristics |
| title_fullStr | Female Asthmatic Patients Have Higher Risk to Develop Gemifloxacin-Associated Skin Rash, Highlighting Unique Delayed Onset Characteristics |
| title_full_unstemmed | Female Asthmatic Patients Have Higher Risk to Develop Gemifloxacin-Associated Skin Rash, Highlighting Unique Delayed Onset Characteristics |
| title_short | Female Asthmatic Patients Have Higher Risk to Develop Gemifloxacin-Associated Skin Rash, Highlighting Unique Delayed Onset Characteristics |
| title_sort | female asthmatic patients have higher risk to develop gemifloxacin associated skin rash highlighting unique delayed onset characteristics |
| topic | Gemifloxacin adverse drug reaction skin rash fluoroquinolones |
| url | https://www.mdpi.com/2079-6382/8/3/134 |
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