Daytime dexmedetomidine sedation with closed-loop acoustic stimulation alters slow wave sleep homeostasis in healthy adults

Daytime dexmedetomidine sedation with closed-loop acoustic stimulation alters slow wave sleep homeostasis in healthy adults

Background: The alpha-2 adrenergic agonist dexmedetomidine induces EEG patterns resembling those of non-rapid eye movement (NREM) sleep. Fulfilment of slow wave sleep (SWS) homeostatic needs would address the assumption that dexmedetomidine induces functional biomimetic sleep states. Methods: In-hom...

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Bibliographic Details
Main Authors: S. Kendall Smith, MohammadMehdi Kafashan, Rachel L. Rios, Emery N. Brown, Eric C. Landsness, Christian S. Guay, Ben Julian A. Palanca
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:BJA Open
Subjects:
closed-loop acoustic stimulation
dexmedetomidine
electroencephalography
sedation
sleep
slow waves
Online Access:http://www.sciencedirect.com/science/article/pii/S2772609624000200

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