Does Apoptosis Play a Role in Varicella Zoster Virus Latency and Reactivation?
Varicella zoster virus (VZV) is an exclusively human highly neurotropic alphaherpesvirus. To date, VZV has been shown to induce apoptosis, primarily through the intrinsic pathway in different cell types, except for neurons in which the virus becomes latent. This review summarizes current studies of...
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| Format: | Article |
| Language: | English |
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MDPI AG
2012-09-01
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| Series: | Viruses |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1999-4915/4/9/1509 |
| _version_ | 1828388947153125376 |
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| author | Stephanie F. James Ravi Mahalingam Don Gilden |
| author_facet | Stephanie F. James Ravi Mahalingam Don Gilden |
| author_sort | Stephanie F. James |
| collection | DOAJ |
| description | Varicella zoster virus (VZV) is an exclusively human highly neurotropic alphaherpesvirus. To date, VZV has been shown to induce apoptosis, primarily through the intrinsic pathway in different cell types, except for neurons in which the virus becomes latent. This review summarizes current studies of varicella-induced apoptosis in non‑neuronal cells. Future studies are proposed to determine whether apoptosis is terminated prematurely or even begins in neurons that are non-productively infected with VZV. |
| first_indexed | 2024-12-10T06:21:19Z |
| format | Article |
| id | doaj.art-c282d93caa2b4eb9a318f1b7c33131b9 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-12-10T06:21:19Z |
| publishDate | 2012-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-c282d93caa2b4eb9a318f1b7c33131b92022-12-22T01:59:20ZengMDPI AGViruses1999-49152012-09-01491509151410.3390/v4091509Does Apoptosis Play a Role in Varicella Zoster Virus Latency and Reactivation?Stephanie F. JamesRavi MahalingamDon GildenVaricella zoster virus (VZV) is an exclusively human highly neurotropic alphaherpesvirus. To date, VZV has been shown to induce apoptosis, primarily through the intrinsic pathway in different cell types, except for neurons in which the virus becomes latent. This review summarizes current studies of varicella-induced apoptosis in non‑neuronal cells. Future studies are proposed to determine whether apoptosis is terminated prematurely or even begins in neurons that are non-productively infected with VZV.http://www.mdpi.com/1999-4915/4/9/1509varicella zoster virusapoptosis |
| spellingShingle | Stephanie F. James Ravi Mahalingam Don Gilden Does Apoptosis Play a Role in Varicella Zoster Virus Latency and Reactivation? Viruses varicella zoster virus apoptosis |
| title | Does Apoptosis Play a Role in Varicella Zoster Virus Latency and Reactivation? |
| title_full | Does Apoptosis Play a Role in Varicella Zoster Virus Latency and Reactivation? |
| title_fullStr | Does Apoptosis Play a Role in Varicella Zoster Virus Latency and Reactivation? |
| title_full_unstemmed | Does Apoptosis Play a Role in Varicella Zoster Virus Latency and Reactivation? |
| title_short | Does Apoptosis Play a Role in Varicella Zoster Virus Latency and Reactivation? |
| title_sort | does apoptosis play a role in varicella zoster virus latency and reactivation |
| topic | varicella zoster virus apoptosis |
| url | http://www.mdpi.com/1999-4915/4/9/1509 |
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