| Summary: | Hydrogen sulfide (H<sub>2</sub>S), as one of the critical gaseous signaling molecules, has important physiological functions in the human body, and abnormal levels of hydrogen sulfide are closely related to tumors, Parkinson’s disease, Alzheimer’s disease, and other diseases. In order to enable the detection of H<sub>2</sub>S in the physiological environment, herein, a new H<sub>2</sub>S fluorescence probe, named <b>C-HS</b>, based on a coumarin–chalcone fluorescence platform was developed. The fluorescence probe provides specific recognition of H<sub>2</sub>S within a wide pH detection range (5.5–8.5), a rapid recognition response (within 10 min) for H<sub>2</sub>S molecules, and a high selectivity for competing species. The probe <b>C-HS</b> possesses low cytotoxicity and is used to achieve the detection of exogenous/ endogenous H<sub>2</sub>S in living cells, indicating that the constructed probe <b>C-HS</b> has the ability to track changes in intracellular H<sub>2</sub>S levels. Therefore, probe <b>C-HS</b> could be a potential tool for the early diagnosis of H<sub>2</sub>S-related diseases.
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