Development of a New Hydrogen Sulfide Fluorescent Probe Based on Coumarin–Chalcone Fluorescence Platform and Its Imaging Application
Hydrogen sulfide (H<sub>2</sub>S), as one of the critical gaseous signaling molecules, has important physiological functions in the human body, and abnormal levels of hydrogen sulfide are closely related to tumors, Parkinson’s disease, Alzheimer’s disease, and other diseases. In order to...
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MDPI AG
2023-08-01
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| Series: | Chemosensors |
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| Online Access: | https://www.mdpi.com/2227-9040/11/8/428 |
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| author | Hanwen Chi Lei Gu Qian Zhang Yonghe Tang Rui Guo Weiying Lin |
| author_facet | Hanwen Chi Lei Gu Qian Zhang Yonghe Tang Rui Guo Weiying Lin |
| author_sort | Hanwen Chi |
| collection | DOAJ |
| description | Hydrogen sulfide (H<sub>2</sub>S), as one of the critical gaseous signaling molecules, has important physiological functions in the human body, and abnormal levels of hydrogen sulfide are closely related to tumors, Parkinson’s disease, Alzheimer’s disease, and other diseases. In order to enable the detection of H<sub>2</sub>S in the physiological environment, herein, a new H<sub>2</sub>S fluorescence probe, named <b>C-HS</b>, based on a coumarin–chalcone fluorescence platform was developed. The fluorescence probe provides specific recognition of H<sub>2</sub>S within a wide pH detection range (5.5–8.5), a rapid recognition response (within 10 min) for H<sub>2</sub>S molecules, and a high selectivity for competing species. The probe <b>C-HS</b> possesses low cytotoxicity and is used to achieve the detection of exogenous/ endogenous H<sub>2</sub>S in living cells, indicating that the constructed probe <b>C-HS</b> has the ability to track changes in intracellular H<sub>2</sub>S levels. Therefore, probe <b>C-HS</b> could be a potential tool for the early diagnosis of H<sub>2</sub>S-related diseases. |
| first_indexed | 2024-03-11T00:02:43Z |
| format | Article |
| id | doaj.art-c284e6e60b2a4413be1db70ca7b09831 |
| institution | Directory Open Access Journal |
| issn | 2227-9040 |
| language | English |
| last_indexed | 2024-03-11T00:02:43Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Chemosensors |
| spelling | doaj.art-c284e6e60b2a4413be1db70ca7b098312023-11-19T00:38:18ZengMDPI AGChemosensors2227-90402023-08-0111842810.3390/chemosensors11080428Development of a New Hydrogen Sulfide Fluorescent Probe Based on Coumarin–Chalcone Fluorescence Platform and Its Imaging ApplicationHanwen Chi0Lei Gu1Qian Zhang2Yonghe Tang3Rui Guo4Weiying Lin5Institute of Optical Materials and Chemical Biology, Guangxi Key Laboratory of Electrochemical Energy Materials, School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, ChinaInstitute of Optical Materials and Chemical Biology, Guangxi Key Laboratory of Electrochemical Energy Materials, School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, ChinaInstitute of Optical Materials and Chemical Biology, Guangxi Key Laboratory of Electrochemical Energy Materials, School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, ChinaInstitute of Optical Materials and Chemical Biology, Guangxi Key Laboratory of Electrochemical Energy Materials, School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, ChinaInstitute of Optical Materials and Chemical Biology, Guangxi Key Laboratory of Electrochemical Energy Materials, School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, ChinaInstitute of Optical Materials and Chemical Biology, Guangxi Key Laboratory of Electrochemical Energy Materials, School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, ChinaHydrogen sulfide (H<sub>2</sub>S), as one of the critical gaseous signaling molecules, has important physiological functions in the human body, and abnormal levels of hydrogen sulfide are closely related to tumors, Parkinson’s disease, Alzheimer’s disease, and other diseases. In order to enable the detection of H<sub>2</sub>S in the physiological environment, herein, a new H<sub>2</sub>S fluorescence probe, named <b>C-HS</b>, based on a coumarin–chalcone fluorescence platform was developed. The fluorescence probe provides specific recognition of H<sub>2</sub>S within a wide pH detection range (5.5–8.5), a rapid recognition response (within 10 min) for H<sub>2</sub>S molecules, and a high selectivity for competing species. The probe <b>C-HS</b> possesses low cytotoxicity and is used to achieve the detection of exogenous/ endogenous H<sub>2</sub>S in living cells, indicating that the constructed probe <b>C-HS</b> has the ability to track changes in intracellular H<sub>2</sub>S levels. Therefore, probe <b>C-HS</b> could be a potential tool for the early diagnosis of H<sub>2</sub>S-related diseases.https://www.mdpi.com/2227-9040/11/8/428fluorescent probephotoinduced electron transfercell imaginghydrogen sulfide |
| spellingShingle | Hanwen Chi Lei Gu Qian Zhang Yonghe Tang Rui Guo Weiying Lin Development of a New Hydrogen Sulfide Fluorescent Probe Based on Coumarin–Chalcone Fluorescence Platform and Its Imaging Application Chemosensors fluorescent probe photoinduced electron transfer cell imaging hydrogen sulfide |
| title | Development of a New Hydrogen Sulfide Fluorescent Probe Based on Coumarin–Chalcone Fluorescence Platform and Its Imaging Application |
| title_full | Development of a New Hydrogen Sulfide Fluorescent Probe Based on Coumarin–Chalcone Fluorescence Platform and Its Imaging Application |
| title_fullStr | Development of a New Hydrogen Sulfide Fluorescent Probe Based on Coumarin–Chalcone Fluorescence Platform and Its Imaging Application |
| title_full_unstemmed | Development of a New Hydrogen Sulfide Fluorescent Probe Based on Coumarin–Chalcone Fluorescence Platform and Its Imaging Application |
| title_short | Development of a New Hydrogen Sulfide Fluorescent Probe Based on Coumarin–Chalcone Fluorescence Platform and Its Imaging Application |
| title_sort | development of a new hydrogen sulfide fluorescent probe based on coumarin chalcone fluorescence platform and its imaging application |
| topic | fluorescent probe photoinduced electron transfer cell imaging hydrogen sulfide |
| url | https://www.mdpi.com/2227-9040/11/8/428 |
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