Antimicrobial Agents in Malignant Otitis Externa: A Systematic Review
This systematic review determined the main antimicrobial agents resulting in MOEand spectrum antimicrobial therapy covering drug resistance in the disease. All thearticles published in three electronic databases, including PubMed, Web of Science,and MEDLINE, were searched within November 15 to Decem...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2021-10-01
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| Series: | Reviews in Clinical Medicine |
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| Online Access: | https://rcm.mums.ac.ir/article_19307_10f5ce4146f86057710b6953f4b764df.pdf |
| _version_ | 1817970256200597504 |
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| author | Mohamad Reza Afzalzadeh |
| author_facet | Mohamad Reza Afzalzadeh |
| author_sort | Mohamad Reza Afzalzadeh |
| collection | DOAJ |
| description | This systematic review determined the main antimicrobial agents resulting in MOEand spectrum antimicrobial therapy covering drug resistance in the disease. All thearticles published in three electronic databases, including PubMed, Web of Science,and MEDLINE, were searched within November 15 to December 15, 2020. Eventually,27 reports were identified assessing the clinical outcomes of patients with MOE.Generally, the mean age of patients with MOE in different studies was within therange of 59–82 years, and the male/female ratio was 1.8:1. The frequency of diabetesamong patients with MOE was within the range of 40%-100%, and the frequency offacial nerve involvement was up to 60.7% in various studies. Pseudomonas aeruginosais the most commonly reported causative organism in MOE. Methicillin-resistantStaphylococcus aureus is another organism leading to MOE. The main concerningissue in antibiotic therapy is the increasing isolation of bacterial strains resistant tothis therapeutic approach. Generally, patients undergoing initial combination therapyhave better outcomes compared to those receiving single therapy. Furthermore, therisk of ciprofloxacin resistance increased, especially when used as a monotherapyagent. The early diagnosis and treatment of patients with MOE are very crucial. Inthis regard, it is necessary to consider the management of diabetes for controllingthe infection with antibiotics and debridement of necrotic tissue. Aggressive surgicalmanagement is suggested in some patients with MOE. |
| first_indexed | 2024-04-13T20:31:30Z |
| format | Article |
| id | doaj.art-c285442999874af69f9836abf03001b6 |
| institution | Directory Open Access Journal |
| issn | 2345-6256 2345-6892 |
| language | English |
| last_indexed | 2024-04-13T20:31:30Z |
| publishDate | 2021-10-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Reviews in Clinical Medicine |
| spelling | doaj.art-c285442999874af69f9836abf03001b62022-12-22T02:31:10ZengMashhad University of Medical SciencesReviews in Clinical Medicine2345-62562345-68922021-10-018414515910.22038/rcm.2021.60083.137419307Antimicrobial Agents in Malignant Otitis Externa: A Systematic ReviewMohamad Reza Afzalzadeh0Sinus and Surgical Endoscopic Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.This systematic review determined the main antimicrobial agents resulting in MOEand spectrum antimicrobial therapy covering drug resistance in the disease. All thearticles published in three electronic databases, including PubMed, Web of Science,and MEDLINE, were searched within November 15 to December 15, 2020. Eventually,27 reports were identified assessing the clinical outcomes of patients with MOE.Generally, the mean age of patients with MOE in different studies was within therange of 59–82 years, and the male/female ratio was 1.8:1. The frequency of diabetesamong patients with MOE was within the range of 40%-100%, and the frequency offacial nerve involvement was up to 60.7% in various studies. Pseudomonas aeruginosais the most commonly reported causative organism in MOE. Methicillin-resistantStaphylococcus aureus is another organism leading to MOE. The main concerningissue in antibiotic therapy is the increasing isolation of bacterial strains resistant tothis therapeutic approach. Generally, patients undergoing initial combination therapyhave better outcomes compared to those receiving single therapy. Furthermore, therisk of ciprofloxacin resistance increased, especially when used as a monotherapyagent. The early diagnosis and treatment of patients with MOE are very crucial. Inthis regard, it is necessary to consider the management of diabetes for controllingthe infection with antibiotics and debridement of necrotic tissue. Aggressive surgicalmanagement is suggested in some patients with MOE.https://rcm.mums.ac.ir/article_19307_10f5ce4146f86057710b6953f4b764df.pdfdiabetes, facial nerve involvementmalignant external otitispseudomonas aeruginosa |
| spellingShingle | Mohamad Reza Afzalzadeh Antimicrobial Agents in Malignant Otitis Externa: A Systematic Review Reviews in Clinical Medicine diabetes, facial nerve involvement malignant external otitis pseudomonas aeruginosa |
| title | Antimicrobial Agents in Malignant Otitis Externa: A Systematic Review |
| title_full | Antimicrobial Agents in Malignant Otitis Externa: A Systematic Review |
| title_fullStr | Antimicrobial Agents in Malignant Otitis Externa: A Systematic Review |
| title_full_unstemmed | Antimicrobial Agents in Malignant Otitis Externa: A Systematic Review |
| title_short | Antimicrobial Agents in Malignant Otitis Externa: A Systematic Review |
| title_sort | antimicrobial agents in malignant otitis externa a systematic review |
| topic | diabetes, facial nerve involvement malignant external otitis pseudomonas aeruginosa |
| url | https://rcm.mums.ac.ir/article_19307_10f5ce4146f86057710b6953f4b764df.pdf |
| work_keys_str_mv | AT mohamadrezaafzalzadeh antimicrobialagentsinmalignantotitisexternaasystematicreview |