Inhibition of Kpnβ1 mediated nuclear import enhances cisplatin chemosensitivity in cervical cancer

Inhibition of Kpnβ1 mediated nuclear import enhances cisplatin chemosensitivity in cervical cancer

Abstract Background Inhibition of nuclear import via Karyopherin beta 1 (Kpnβ1) shows potential as an anti-cancer approach. This study investigated the use of nuclear import inhibitor, INI-43, in combination with cisplatin. Methods Cervical cancer cells were pre-treated with INI-43 before treatment...

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Bibliographic Details
Main Authors: Ru-pin Alicia Chi, Pauline van der Watt, Wei Wei, Michael J. Birrer, Virna D. Leaner
Format: Article
Language:English
Published: BMC 2021-02-01
Series:BMC Cancer
Subjects:
Cisplatin
INI-43
Nuclear import
p53
NFκB
Cervical cancer
Online Access:https://doi.org/10.1186/s12885-021-07819-3

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