Effect of miR‐34b/c rs4938723 T > C on pediatric glioma susceptibility
Abstract Gliomas, the most common type of primary intracranial tumor, arise from the brain's glial cells and constitute 30% of all brain and central nervous system tumors. MiR‐34b/c plays an important role in colorectal cancer and other cancers, but its role in glioma is unknown. In this study,...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-06-01
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| Series: | Precision Medical Sciences |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/prm2.12067 |
| _version_ | 1811338351146434560 |
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| author | Xingyu Jia Wenchao Chen Wei Chen Yuxiang Liao Jingying Zhou Li Yuan Huiran Lin Jun Bian |
| author_facet | Xingyu Jia Wenchao Chen Wei Chen Yuxiang Liao Jingying Zhou Li Yuan Huiran Lin Jun Bian |
| author_sort | Xingyu Jia |
| collection | DOAJ |
| description | Abstract Gliomas, the most common type of primary intracranial tumor, arise from the brain's glial cells and constitute 30% of all brain and central nervous system tumors. MiR‐34b/c plays an important role in colorectal cancer and other cancers, but its role in glioma is unknown. In this study, we attempted to assess the effect of rs4938723 T > C in miR‐34b/c on the susceptibility of glioma Chinese children. Odds ratios and 95% confidence intervals (CIs) were calculated to evaluate the association between the selected polymorphism and glioma susceptibility. Our results showed that there is no significant association between this polymorphism and the risk of glioma in Chinese children. However, stratified analysis showed that the rs4938723 TC/CC genotype significantly reduced the risk of glioma in participants under 60 months of age (adjusted OR = 0.56, 95% CI = 0.35–0.88, p = .013). Overall, our study indicates that miR‐34b/c rs4938723 T > C polymorphism may have a weak influence on glioma susceptibility. Nevertheless, these findings need to be validated in well‐designed studies with larger sample sizes and different populations. |
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| format | Article |
| id | doaj.art-c288e894e4944e19b2f4eab8cb40ae40 |
| institution | Directory Open Access Journal |
| issn | 2642-2514 |
| language | English |
| last_indexed | 2024-04-13T18:09:39Z |
| publishDate | 2022-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Precision Medical Sciences |
| spelling | doaj.art-c288e894e4944e19b2f4eab8cb40ae402022-12-22T02:35:58ZengWileyPrecision Medical Sciences2642-25142022-06-01112828610.1002/prm2.12067Effect of miR‐34b/c rs4938723 T > C on pediatric glioma susceptibilityXingyu Jia0Wenchao Chen1Wei Chen2Yuxiang Liao3Jingying Zhou4Li Yuan5Huiran Lin6Jun Bian7Department of Pathology, Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou Guangdong ChinaDepartment of Pediatrics The First Affiliated Hospital of Jinan University Guangzhou ChinaDepartment of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou Guangdong ChinaDepartment of Neurosurgery, Xiangya Hospital Central South University Changsha ChinaDepartment of Hematology The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Zhejiang ChinaDepartment of Pathology, Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou Guangdong ChinaFaculty of Medicine Macau University of Science and Technology Macau ChinaDepartment of General Surgery, Xi'an Children's Hospital Xi'an Jiaotong University Affiliated Children's Hospital Xi'an Shaanxi ChinaAbstract Gliomas, the most common type of primary intracranial tumor, arise from the brain's glial cells and constitute 30% of all brain and central nervous system tumors. MiR‐34b/c plays an important role in colorectal cancer and other cancers, but its role in glioma is unknown. In this study, we attempted to assess the effect of rs4938723 T > C in miR‐34b/c on the susceptibility of glioma Chinese children. Odds ratios and 95% confidence intervals (CIs) were calculated to evaluate the association between the selected polymorphism and glioma susceptibility. Our results showed that there is no significant association between this polymorphism and the risk of glioma in Chinese children. However, stratified analysis showed that the rs4938723 TC/CC genotype significantly reduced the risk of glioma in participants under 60 months of age (adjusted OR = 0.56, 95% CI = 0.35–0.88, p = .013). Overall, our study indicates that miR‐34b/c rs4938723 T > C polymorphism may have a weak influence on glioma susceptibility. Nevertheless, these findings need to be validated in well‐designed studies with larger sample sizes and different populations.https://doi.org/10.1002/prm2.12067gliomamiR‐34b/cpolymorphismrs4938723susceptibility |
| spellingShingle | Xingyu Jia Wenchao Chen Wei Chen Yuxiang Liao Jingying Zhou Li Yuan Huiran Lin Jun Bian Effect of miR‐34b/c rs4938723 T > C on pediatric glioma susceptibility Precision Medical Sciences glioma miR‐34b/c polymorphism rs4938723 susceptibility |
| title | Effect of miR‐34b/c rs4938723 T > C on pediatric glioma susceptibility |
| title_full | Effect of miR‐34b/c rs4938723 T > C on pediatric glioma susceptibility |
| title_fullStr | Effect of miR‐34b/c rs4938723 T > C on pediatric glioma susceptibility |
| title_full_unstemmed | Effect of miR‐34b/c rs4938723 T > C on pediatric glioma susceptibility |
| title_short | Effect of miR‐34b/c rs4938723 T > C on pediatric glioma susceptibility |
| title_sort | effect of mir 34b c rs4938723 t c on pediatric glioma susceptibility |
| topic | glioma miR‐34b/c polymorphism rs4938723 susceptibility |
| url | https://doi.org/10.1002/prm2.12067 |
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