Differential decline of lung function in COPD patients according to structural abnormality in chest CT
Background: Different progressions or prognoses of chronic obstructive pulmonary disease (COPD) have been reported according to structural abnormalities based on chest computed tomography (CT). This study aimed to investigate whether different structural abnormalities independently affect annual lun...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024037149 |
| _version_ | 1797247828956807168 |
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| author | Hyun Woo Lee Jung-Kyu Lee Youlim Kim An-Soo Jang Yong il Hwang Jae Ha Lee Ki-Suck Jung Kwang Ha Yoo Hyoung Kyu Yoon Deog Kyeom Kim |
| author_facet | Hyun Woo Lee Jung-Kyu Lee Youlim Kim An-Soo Jang Yong il Hwang Jae Ha Lee Ki-Suck Jung Kwang Ha Yoo Hyoung Kyu Yoon Deog Kyeom Kim |
| author_sort | Hyun Woo Lee |
| collection | DOAJ |
| description | Background: Different progressions or prognoses of chronic obstructive pulmonary disease (COPD) have been reported according to structural abnormalities based on chest computed tomography (CT). This study aimed to investigate whether different structural abnormalities independently affect annual lung function changes and clinical prognosis in patients with COPD. Methods: This longitudinal multicenter observational study was conducted using the KOCOSS cohort (NCT02800499) database in Korea from January 2012 to December 2019. For COPD patients with chest CT findings at baseline enrolment and longitudinal spirometric data, annual forced expiratory volume in 1 s (FEV1) decline rate (mL/year) and clinical outcomes were compared according to structural abnormalities, including emphysema, bronchiectasis (BE), and tuberculosis-destroyed lung (TDL). We estimated the adjusted annual FEV1 changes using a mixed-effect linear regression model. Results: Among the enrolled 237 patients, 152 showed structural abnormalities. Emphysema, BE, and TDL were observed in 119 (78.3%), 28 (18.4%), and 27 (17.8%) patients, respectively. The annual decline in FEV1 was faster in COPD patients with structural abnormalities than those without (β = −70.6 mL/year, P-value = 0.039). BE/TDL-dominant or emphysema-dominant structural abnormality contributed to an accelerated annual FEV1 decline compared to no structural abnormality (BE/TDL-dominant, β = −103.7 mL/year, P-value = 0.043; emphysema-dominant, β = −84.1 mL/year, P-value = 0.018). Structural abnormalities made no significant differences in acute exacerbation rate and mortality. Conclusion: The lung function decline rate in COPD differed according to structural abnormalities on CT. These findings may suggest that more focus should be placed on earlier intervention or regular follow-up with spirometry in COPD patients with BE or TDL on chest CT. |
| first_indexed | 2024-04-24T20:04:54Z |
| format | Article |
| id | doaj.art-c288eaef4e1d4d1f8896ff54a826dea6 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-24T20:04:54Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-c288eaef4e1d4d1f8896ff54a826dea62024-03-24T06:59:33ZengElsevierHeliyon2405-84402024-04-01107e27683Differential decline of lung function in COPD patients according to structural abnormality in chest CTHyun Woo Lee0Jung-Kyu Lee1Youlim Kim2An-Soo Jang3Yong il Hwang4Jae Ha Lee5Ki-Suck Jung6Kwang Ha Yoo7Hyoung Kyu Yoon8Deog Kyeom Kim9Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul, South KoreaDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul, South KoreaDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Konkuk University Hospital, School of Medicine, Konkuk University, Seoul, South KoreaDepartment of Pulmonology and Allergy, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, South KoreaDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, South KoreaDivision of Pulmonology, Department of Internal Medicine, Inje University Haeundae Paik Hospital, University of Inje College of Medicine, Busan, South KoreaDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, South KoreaDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Konkuk University Hospital, School of Medicine, Konkuk University, Seoul, South KoreaDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Yeouido St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, South KoreaDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul, South Korea; Corresponding author. Division of Respiratory and Critical Care, Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, 20 Boramae-ro-5-gil, Dongjak-gu, Seoul, 07061, South Korea.Background: Different progressions or prognoses of chronic obstructive pulmonary disease (COPD) have been reported according to structural abnormalities based on chest computed tomography (CT). This study aimed to investigate whether different structural abnormalities independently affect annual lung function changes and clinical prognosis in patients with COPD. Methods: This longitudinal multicenter observational study was conducted using the KOCOSS cohort (NCT02800499) database in Korea from January 2012 to December 2019. For COPD patients with chest CT findings at baseline enrolment and longitudinal spirometric data, annual forced expiratory volume in 1 s (FEV1) decline rate (mL/year) and clinical outcomes were compared according to structural abnormalities, including emphysema, bronchiectasis (BE), and tuberculosis-destroyed lung (TDL). We estimated the adjusted annual FEV1 changes using a mixed-effect linear regression model. Results: Among the enrolled 237 patients, 152 showed structural abnormalities. Emphysema, BE, and TDL were observed in 119 (78.3%), 28 (18.4%), and 27 (17.8%) patients, respectively. The annual decline in FEV1 was faster in COPD patients with structural abnormalities than those without (β = −70.6 mL/year, P-value = 0.039). BE/TDL-dominant or emphysema-dominant structural abnormality contributed to an accelerated annual FEV1 decline compared to no structural abnormality (BE/TDL-dominant, β = −103.7 mL/year, P-value = 0.043; emphysema-dominant, β = −84.1 mL/year, P-value = 0.018). Structural abnormalities made no significant differences in acute exacerbation rate and mortality. Conclusion: The lung function decline rate in COPD differed according to structural abnormalities on CT. These findings may suggest that more focus should be placed on earlier intervention or regular follow-up with spirometry in COPD patients with BE or TDL on chest CT.http://www.sciencedirect.com/science/article/pii/S2405844024037149Forced expiratory volumeRespiratory function testsBronchiectasisPulmonary emphysemaPulmonary diseaseChronic obstructive |
| spellingShingle | Hyun Woo Lee Jung-Kyu Lee Youlim Kim An-Soo Jang Yong il Hwang Jae Ha Lee Ki-Suck Jung Kwang Ha Yoo Hyoung Kyu Yoon Deog Kyeom Kim Differential decline of lung function in COPD patients according to structural abnormality in chest CT Heliyon Forced expiratory volume Respiratory function tests Bronchiectasis Pulmonary emphysema Pulmonary disease Chronic obstructive |
| title | Differential decline of lung function in COPD patients according to structural abnormality in chest CT |
| title_full | Differential decline of lung function in COPD patients according to structural abnormality in chest CT |
| title_fullStr | Differential decline of lung function in COPD patients according to structural abnormality in chest CT |
| title_full_unstemmed | Differential decline of lung function in COPD patients according to structural abnormality in chest CT |
| title_short | Differential decline of lung function in COPD patients according to structural abnormality in chest CT |
| title_sort | differential decline of lung function in copd patients according to structural abnormality in chest ct |
| topic | Forced expiratory volume Respiratory function tests Bronchiectasis Pulmonary emphysema Pulmonary disease Chronic obstructive |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024037149 |
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