Actin-Interacting Amphidinolides: Syntheses and Mechanisms of Action of Amphidinolides X, J, and K
Amphidinolides are a family of more than forty macrolides of varying sizes and complex structures isolated from dinoflagellates of the genus <i>Amphidinium</i>. Although all of them display potent-to-moderate cytotoxicity, their full bioactivity profile and mode of action have not been f...
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| Format: | Article |
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MDPI AG
2023-07-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/13/5249 |
| _version_ | 1797591162352041984 |
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| author | Anna M. Costa |
| author_facet | Anna M. Costa |
| author_sort | Anna M. Costa |
| collection | DOAJ |
| description | Amphidinolides are a family of more than forty macrolides of varying sizes and complex structures isolated from dinoflagellates of the genus <i>Amphidinium</i>. Although all of them display potent-to-moderate cytotoxicity, their full bioactivity profile and mode of action have not been fully investigated. Access to enough material is needed for these studies, but samples of these compounds are limited due to the minute amounts that can only be obtained by either large-scale cultivation of the organism that produces them or by total synthesis. Of all the amphidinolides known to date, only the targets of five of them (B1, H1, J, K, and X) have been examined and all have been found to interact with actin, a crucial cytoskeletal protein. This paper reviews what is currently known about actin-interacting amphidinolides, with a focus on the research of our group. Amphidinolides J and X are F-actin destabilizers, whereas Amphidinolides H1 and K stabilize actin filaments, likely via different mechanisms. More precise details of the interaction between amphidinolides and actin are missing. |
| first_indexed | 2024-03-11T01:33:36Z |
| format | Article |
| id | doaj.art-c28910a5ce234208ab7cc9277277f98f |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T01:33:36Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-c28910a5ce234208ab7cc9277277f98f2023-11-18T17:10:24ZengMDPI AGMolecules1420-30492023-07-012813524910.3390/molecules28135249Actin-Interacting Amphidinolides: Syntheses and Mechanisms of Action of Amphidinolides X, J, and KAnna M. Costa0Organic Chemistry Section, Department of Inorganic and Organic Chemistry, Facultat de Química, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Catalonia, SpainAmphidinolides are a family of more than forty macrolides of varying sizes and complex structures isolated from dinoflagellates of the genus <i>Amphidinium</i>. Although all of them display potent-to-moderate cytotoxicity, their full bioactivity profile and mode of action have not been fully investigated. Access to enough material is needed for these studies, but samples of these compounds are limited due to the minute amounts that can only be obtained by either large-scale cultivation of the organism that produces them or by total synthesis. Of all the amphidinolides known to date, only the targets of five of them (B1, H1, J, K, and X) have been examined and all have been found to interact with actin, a crucial cytoskeletal protein. This paper reviews what is currently known about actin-interacting amphidinolides, with a focus on the research of our group. Amphidinolides J and X are F-actin destabilizers, whereas Amphidinolides H1 and K stabilize actin filaments, likely via different mechanisms. More precise details of the interaction between amphidinolides and actin are missing.https://www.mdpi.com/1420-3049/28/13/5249G-actin/F-actin equilibriumactin stabilizers and destabilizerstotal synthesisamphidinolides |
| spellingShingle | Anna M. Costa Actin-Interacting Amphidinolides: Syntheses and Mechanisms of Action of Amphidinolides X, J, and K Molecules G-actin/F-actin equilibrium actin stabilizers and destabilizers total synthesis amphidinolides |
| title | Actin-Interacting Amphidinolides: Syntheses and Mechanisms of Action of Amphidinolides X, J, and K |
| title_full | Actin-Interacting Amphidinolides: Syntheses and Mechanisms of Action of Amphidinolides X, J, and K |
| title_fullStr | Actin-Interacting Amphidinolides: Syntheses and Mechanisms of Action of Amphidinolides X, J, and K |
| title_full_unstemmed | Actin-Interacting Amphidinolides: Syntheses and Mechanisms of Action of Amphidinolides X, J, and K |
| title_short | Actin-Interacting Amphidinolides: Syntheses and Mechanisms of Action of Amphidinolides X, J, and K |
| title_sort | actin interacting amphidinolides syntheses and mechanisms of action of amphidinolides x j and k |
| topic | G-actin/F-actin equilibrium actin stabilizers and destabilizers total synthesis amphidinolides |
| url | https://www.mdpi.com/1420-3049/28/13/5249 |
| work_keys_str_mv | AT annamcosta actininteractingamphidinolidessynthesesandmechanismsofactionofamphidinolidesxjandk |