A cancer-specific anti-podocalyxin monoclonal antibody (60-mG2a-f) exerts antitumor effects in mouse xenograft models of pancreatic carcinoma

A cancer-specific anti-podocalyxin monoclonal antibody (60-mG2a-f) exerts antitumor effects in mouse xenograft models of pancreatic carcinoma

Overexpression of podocalyxin (PODXL) is associated with progression, metastasis, and poor outcomes in several cancers. PODXL also plays an important role in the development of normal tissues. For antibody-based therapy to target PODXL-expressing cancers using monoclonal antibodies (mAbs), cancer-sp...

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Bibliographic Details
Main Authors: Mika K. Kaneko, Tomokazu Ohishi, Manabu Kawada, Yukinari Kato
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Biochemistry and Biophysics Reports
Subjects:
Podocalyxin
PODXL
Monoclonal antibody
Cancer-specific mAb
Pancreatic cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580820301369

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