Highly Water-Absorptive and Antibacterial Hydrogel Dressings for Rapid Postoperative Detumescence
Postoperative wound edema, infection, and pain burden the patient’s life. Therefore, the purpose of this study is to develop an effective antibacterial, multifunctional application to prevent postoperative edema and relieve postoperative pain by making full use of the dehydrating and analgesic effec...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.845345/full |
| _version_ | 1818205829201920000 |
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| author | Yuan Fang Yuan Fang Haibo Li Haibo Li Jingting Chen Yao Xiong Xu Li Jianda Zhou Shengli Li Shoubao Wang Binbin Sun Binbin Sun |
| author_facet | Yuan Fang Yuan Fang Haibo Li Haibo Li Jingting Chen Yao Xiong Xu Li Jianda Zhou Shengli Li Shoubao Wang Binbin Sun Binbin Sun |
| author_sort | Yuan Fang |
| collection | DOAJ |
| description | Postoperative wound edema, infection, and pain burden the patient’s life. Therefore, the purpose of this study is to develop an effective antibacterial, multifunctional application to prevent postoperative edema and relieve postoperative pain by making full use of the dehydrating and analgesic effects of magnesium sulfate (MgSO4), magnesium oxide (MgO), sodium alginate (SA), and sodium carboxymethyl cellulose (Na-CMC) to make a composite hydrogel, which can promote postoperative detumescence. MgSO4//MgO/SA/Na-CMC composite hydrogel dressings have outstanding mechanical properties, high water absorption, and good biocompatibility. MgO endows the hydrogel dressing with excellent antibacterial properties and better antibacterial activity against common bacteria and multidrug-resistant bacteria. In addition, MgSO4/MgO/SA/Na-CMC hydrogel dressing shows superior dehydration and analgesic properties in the postoperative nude mice model. This study shows that the multifunctional MgSO4/MgO/SA/Na-CMC composite hydrogel dressing developed as a surgical incision dressing has broad prospects in the prevention of incision infection, postoperative edema, and analgesia. |
| first_indexed | 2024-12-12T04:03:21Z |
| format | Article |
| id | doaj.art-c28b21b77747474dbee8f92389e67ce0 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-12-12T04:03:21Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-c28b21b77747474dbee8f92389e67ce02022-12-22T00:38:53ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-05-011010.3389/fbioe.2022.845345845345Highly Water-Absorptive and Antibacterial Hydrogel Dressings for Rapid Postoperative DetumescenceYuan Fang0Yuan Fang1Haibo Li2Haibo Li3Jingting Chen4Yao Xiong5Xu Li6Jianda Zhou7Shengli Li8Shoubao Wang9Binbin Sun10Binbin Sun11Department of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Plastic Surgery, The Third Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Plastic Surgery, The Third Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Plastic Surgery, The Third Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Plastic Surgery, The Third Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Orthopaedics, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaCollage of Biological Science and Medical Engineering, Donghua University, Shanghai, ChinaPostoperative wound edema, infection, and pain burden the patient’s life. Therefore, the purpose of this study is to develop an effective antibacterial, multifunctional application to prevent postoperative edema and relieve postoperative pain by making full use of the dehydrating and analgesic effects of magnesium sulfate (MgSO4), magnesium oxide (MgO), sodium alginate (SA), and sodium carboxymethyl cellulose (Na-CMC) to make a composite hydrogel, which can promote postoperative detumescence. MgSO4//MgO/SA/Na-CMC composite hydrogel dressings have outstanding mechanical properties, high water absorption, and good biocompatibility. MgO endows the hydrogel dressing with excellent antibacterial properties and better antibacterial activity against common bacteria and multidrug-resistant bacteria. In addition, MgSO4/MgO/SA/Na-CMC hydrogel dressing shows superior dehydration and analgesic properties in the postoperative nude mice model. This study shows that the multifunctional MgSO4/MgO/SA/Na-CMC composite hydrogel dressing developed as a surgical incision dressing has broad prospects in the prevention of incision infection, postoperative edema, and analgesia.https://www.frontiersin.org/articles/10.3389/fbioe.2022.845345/fullhydrogeldetumescenceantibacterialMgSO4MgO |
| spellingShingle | Yuan Fang Yuan Fang Haibo Li Haibo Li Jingting Chen Yao Xiong Xu Li Jianda Zhou Shengli Li Shoubao Wang Binbin Sun Binbin Sun Highly Water-Absorptive and Antibacterial Hydrogel Dressings for Rapid Postoperative Detumescence Frontiers in Bioengineering and Biotechnology hydrogel detumescence antibacterial MgSO4 MgO |
| title | Highly Water-Absorptive and Antibacterial Hydrogel Dressings for Rapid Postoperative Detumescence |
| title_full | Highly Water-Absorptive and Antibacterial Hydrogel Dressings for Rapid Postoperative Detumescence |
| title_fullStr | Highly Water-Absorptive and Antibacterial Hydrogel Dressings for Rapid Postoperative Detumescence |
| title_full_unstemmed | Highly Water-Absorptive and Antibacterial Hydrogel Dressings for Rapid Postoperative Detumescence |
| title_short | Highly Water-Absorptive and Antibacterial Hydrogel Dressings for Rapid Postoperative Detumescence |
| title_sort | highly water absorptive and antibacterial hydrogel dressings for rapid postoperative detumescence |
| topic | hydrogel detumescence antibacterial MgSO4 MgO |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.845345/full |
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